DegronMD

Uniprot ID: O14526

Source protein: F-BAR domain only protein 1

Source gene: FCHO1

Class: DEG_SCF_TRCP1_1

Location: 474:479

E3 ligase: BTRC

DEGRON score: 0.9627

ASA_SCORE: 78.8167

COIL: 0.9122

CONS_SCORE: 0.2552

DSS_SCORE: 0.7573

HELIX: 0.0723

FCONS_SCORE: 0.8541

RIG_SCORE: 0.5413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A484G	DO222662	MELA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.P487T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	0.1111
p.P487T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.1111
p.P489R	SIDM00056	Thyroid Gland Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.P489R	ACH-002148	Thyroid Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.P489R	K5	thyroid	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.D478N	ACH-000018	Bladder Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	0.5821
p.S474L	MDA-MB-415	breast	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SCF_TRCP1_1	474:479	DSGLDS	BTRC	0.9627	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SCF_TRCP1_1	220:225	DSGLDS	BTRC	0.8594	More...
P25963	NF-kappa-B inhibitor alpha	DEG_SCF_TRCP1_1	31:36	DSGLDS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons