DegronMD - P25963(NFKBIA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D31N	TCGA-E2-A159	BRCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.6932
p.D31N	DO2808	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.6932
p.E41K	TCGA-FD-A3B6	BLCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1944
p.E41K	DO458	BLCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1944
p.Y42C	TCGA-G4-6304	COAD	TCGA	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation blocking phosphorylation signal	0.6111
p.Y42C	DO10639	COAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation blocking phosphorylation signal	0.6111
p.D27H	TCGA-GS-A9TZ	DLBC	TCGA	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.2222
p.D27H	DO219918	DLBC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.2222
p.P34R	DO224841	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.7512
p.P34R	DO227776	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.7512
p.A28D	DO229027	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.25
p.R29S	DO229037	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.2778
p.P24Q	DO229008	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389
p.P24Q	HCT-15	large intestine	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389
p.D31G	DO50952	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.7198
p.L41P	DO23196	LINC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1944
p.A43T	DO52686	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389
p.A43V	DO228605	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389
p.K38T	DO232761	PBCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation blocking ubiquitination signal	0.7222
p.R24W	DO229229	THCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389
p.D46N	DO43162	UCEC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.0556
p.L26M	SIDM00290	Gastric Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1944
p.G42R	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation blocking phosphorylation signal	0.6111
p.G42E	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation blocking phosphorylation signal	0.6111
p.E35G	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation altering degron motif	0.7199
p.P24L	NCI-H740	lung	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	31:36	Mutation rewiring degron network	0.1389

Kaplan plot for NFKBIA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFKBIA

UniProt ID: P25963

Entrez ID: 4792

Protein name: NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFKBIA in