DegronMD

Uniprot ID: P25963

Source protein: NF-kappa-B inhibitor alpha

Source gene: NFKBIA

Class: DEG_SCF_TRCP1_1

Location: 31:36

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 48.5333

COIL: 0.7573

CONS_SCORE: 0.783

DSS_SCORE: 0.5996

HELIX: 0.1907

FCONS_SCORE: 1.3576

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D31N	TCGA-E2-A159	BRCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.6932
p.D31N	DO2808	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6932
p.E41K	TCGA-FD-A3B6	BLCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.E41K	DO458	BLCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.Y42C	TCGA-G4-6304	COAD	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.6111
p.Y42C	DO10639	COAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6111
p.D27H	TCGA-GS-A9TZ	DLBC	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.D27H	DO219918	DLBC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.P34R	DO224841	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7512
p.P34R	DO227776	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7512
p.A28D	DO229027	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.25
p.R29S	DO229037	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2778
p.P24Q	DO229008	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1389
p.P24Q	HCT-15	large_intestine	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.1389
p.D31G	DO50952	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7198
p.L41P	DO23196	LINC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.A43T	DO52686	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1389
p.A43V	DO228605	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1389
p.K38T	DO232761	PBCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7222
p.R24W	DO229229	THCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1389
p.D46N	DO43162	UCEC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.L26M	SIDM00290	Gastric Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.G42R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.6111
p.G42E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.6111
p.E35G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.7199
p.P24L	NCI-H740	lung	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SCF_TRCP1_1	474:479	DSGLDS	BTRC	0.9627	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SCF_TRCP1_1	220:225	DSGLDS	BTRC	0.8594	More...
P25963	NF-kappa-B inhibitor alpha	DEG_SCF_TRCP1_1	31:36	DSGLDS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons