DegronMD - O15085(ARHGEF11)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1442R	TCGA-17-Z055	LUAD	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation rewiring degron network	0.2222
p.R1449H	TCGA-33-4566	LUSC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8244
p.R216L	TCGA-49-AARQ	LUAD	TCGA	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation blocking phosphorylation signal	0.6667
p.R216L	DO51189	LUAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation blocking phosphorylation signal	0.6667
p.S652C	TCGA-55-7907	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation altering degron motif	0.7541
p.D546Y	TCGA-66-2787	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7325
p.E537K	TCGA-85-A4CL	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.R663W	TCGA-A5-A1OF	UCEC	TCGA	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation blocking phosphorylation signal	0.6667
p.R663W	TCGA-A5-A1OF	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation blocking phosphorylation signal	0.5833
p.R663W	TCGA-BR-6452	STAD	TCGA	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation blocking phosphorylation signal	0.6667
p.R663W	TCGA-BR-6452	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation blocking phosphorylation signal	0.5833
p.R663W	TCGA-HU-A4GQ	STAD	TCGA	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation blocking phosphorylation signal	0.6667
p.R663W	TCGA-HU-A4GQ	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation blocking phosphorylation signal	0.5833
p.L1237H	TCGA-A8-A085	BRCA	TCGA	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation altering degron motif	0.7313
p.E1246D	TCGA-AC-A23H	BRCA	TCGA	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.1389
p.R648C	TCGA-AN-A046	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.2222
p.R648C	TCGA-DF-A2KU	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.2222
p.A1227T	TCGA-AP-A051	UCEC	TCGA	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.1389
p.R1452H	TCGA-AP-A1DK	UCEC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8244
p.R1452H	TCGA-E2-A155	BRCA	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8244
p.K557N	TCGA-AP-A1DV	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.R651H	TCGA-AX-A3FT	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation blocking phosphorylation signal	0.75
p.R202W	TCGA-BR-6452	STAD	TCGA	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.8634
p.R202W	DO219873	SKCA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.8634
p.R202W	DO38404	STAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.8634
p.L222V	TCGA-D9-A6EC	SKCM	TCGA	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6765
p.L222V	DO50291	SKCM	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6765
p.R672C	TCGA-DA-A1I7	SKCM	TCGA	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.8301
p.D1244N	TCGA-EE-A3AA	SKCM	TCGA	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.1944
p.G232V	TCGA-FF-8046	DLBC	TCGA	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation blocking phosphorylation signal	0.5833
p.G232V	DO222303	DLBC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation blocking phosphorylation signal	0.5833
p.D1445N	TCGA-FI-A2D0	UCEC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation rewiring degron network	0.3056
p.E653K	TCGA-GF-A6C9	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation altering degron motif	0.7022
p.K225N	TCGA-GU-A766	BLCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6918
p.K225N	DO51891	BLCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6918
p.L655P	TCGA-UY-A78N	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	652:656	Mutation altering degron motif	0.7582
p.D227Y	DO6144	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2778
p.R229C	DO9010	COAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.R229C	DO233903	GACA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.R229C	DO228253	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.S207F	DO8898	COAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1944
p.S207F	DO37835	SKCM	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1944
p.Q221E	DO224801	COCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6744
p.R188Q	DO234462	ESAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.0833
p.E677K	DO222739	ESCA	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1944
p.G676C	DO11585	GBM	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.2222
p.E213K	DO49683	LIAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation blocking phosphorylation signal	0.5833
p.A643D	DO228974	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0833
p.S201R	DO228974	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7427
p.S201R	DO32831	PACA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7427
p.R195S	DO229028	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.T203N	DO229024	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.3056
p.D648E	DO229037	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.2222
p.S225F	DO229052	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.7982
p.S234C	DO52193	LIHC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.0833
p.G235V	DO231708	LINC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.0556
p.G550E	DO24527	LUAD	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.25
p.G550V	DO26230	LUAD	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.25
p.S661F	DO26210	LUAD	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1667
p.S661F	DO26210	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1944
p.I536M	DO222494	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.S551Y	DO222714	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2222
p.D202G	DO51705	PAAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7198
p.R206S	DO33032	PACA	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2222
p.P663L	DO233535	PRAD	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation blocking phosphorylation signal	0.6667
p.P663L	DO233535	PRAD	ICGC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation blocking phosphorylation signal	0.5833
p.P543L	DO37667	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7582
p.G226V	DO37831	SKCM	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.3056
p.G670E	DO47563	SKCM	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.7199
p.L194F	DO219460	SKCM	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.P543S	DO38707	STAD	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.6752
p.K223R	DO47849	STAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.7237
p.P196L	DO42280	UCEC	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.3056
p.S547Y	DO41644	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.712
p.F230L	DO42568	UCEC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.1944
p.P207L	DO41331	UCEC	ICGC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1944
p.D665G	DO41379	UCEC	ICGC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.2778
p.D665G	DO41379	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0833
p.R195C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.R195C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.2778
p.R1449C	SIDM00401	Melanoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	SIDM00945	Colorectal Carcinoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	ACH-000614	Skin Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	ACH-000895	Colon/Colorectal Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	ACH-002461	Skin Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	CL-34	large intestine	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1449C	RVH-421	skin	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R644C	SIDM01174	Cervical Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1111
p.R644C	ACH-001402	Cervical Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1111
p.R644C	SW756	cervix	COSMIC	ASSST	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1111
p.A205T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.25
p.R1452C	SIDM00950	Pancreatic Carcinoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.R1452C	ACH-000243	Pancreatic Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.8301
p.Q540R	SIDM00945	Colorectal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.25
p.Q540R	CL-34	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.25
p.H1225Y	SIDM00350	Head and Neck Carcinoma	GDSC	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.0833
p.H1225Y	SAT	upper aerodigestive tract	COSMIC	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.0833
p.E668D	SIDM00889	Cervical Carcinoma	GDSC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.6758
p.E668D	ACH-001333	Cervical Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.6758
p.E668D	C-33-A	cervix	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.6758
p.E229K	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.E229K	ACH-000544	Esophageal Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.E229K	OE21	oesophagus	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.2222
p.P1450L	SIDM01019	Acute Myeloid Leukemia	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.7582
p.P1450L	ACH-002258	Leukemia	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.7582
p.P1450L	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation altering degron motif	0.7582
p.R202Q	SIDM00363	Acute Myeloid Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7329
p.R202Q	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation altering degron motif	0.7329
p.V1462A	SIDM01746	Osteosarcoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation blocking phosphorylation signal	0.5556
p.V1462A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation blocking phosphorylation signal	0.5556
p.P1236S	ACH-000904	Lung Cancer	CCLE	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation altering degron motif	0.6752
p.P1236S	NCI-H1770	lung	COSMIC	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation altering degron motif	0.6752
p.Q1439H	ACH-001061	Colon/Colorectal Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation rewiring degron network	0.1389
p.E210A	ACH-001450	Lymphoma	CCLE	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.0556
p.E210A	ACH-001450	Lymphoma	CCLE	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1111
p.R672H	ACH-001610	Brain Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.8244
p.D678V	ACH-001624	Brain Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1667
p.F551L	ACH-002394	Colon/Colorectal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2222
p.F551L	GEO	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2222
p.P557H	NCI-H1581	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.R677C	NY	bone	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1944
p.R677C	RERF-LC-Sq1	lung	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1944
p.R677C	SNU-81	large intestine	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1944
p.R677C	JHH-1	liver	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1944
p.I680N	ROS-50	haematopoietic and lymphoid tissue	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.1111
p.P554S	CW-2	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.E209Q	H513	pleura	COSMIC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.1389
p.L214V	UM-UC-3	urinary tract	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.1667
p.V1464M	OC-314	ovary	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	1446:1454	Mutation rewiring degron network	0.0556
p.R211Q	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation rewiring degron network	0.0833
p.R211Q	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	197:202	Mutation rewiring degron network	0.0833
p.D224H	OVTOKO	ovary	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	220:225	Mutation altering degron motif	0.6577
p.E681V	U-118-MG	central nervous system	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation rewiring degron network	0.0833
p.T668S	HCC1428	breast	COSMIC	PTPPFT	DEG_SCF_FBW7_1	667:672	Mutation altering degron motif	0.8227
p.D1233N	TGW	autonomic ganglia	COSMIC	LTPTPS	DEG_SCF_FBW7_1	1234:1239	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF11

UniProt ID: O15085

Entrez ID: 9826

Protein name: Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF11 in