DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: DEG_SPOP_SBC_1

Location: 652:656

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 76.12

COIL: 0.842

CONS_SCORE: 0.4355

DSS_SCORE: 0.6485

HELIX: 0.1268

FCONS_SCORE: 1.1718

RIG_SCORE: 0.5402

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L655P	TCGA-UY-A78N	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	0.7582
p.S652C	TCGA-55-7907	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.7541
p.R651H	TCGA-AX-A3FT	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.75
p.E653K	TCGA-GF-A6C9	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.R663W	TCGA-A5-A1OF	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.5833
p.R663W	TCGA-BR-6452	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.5833
p.R663W	TCGA-HU-A4GQ	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.5833
p.P663L	DO233535	PRAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.5833
p.R648C	TCGA-AN-A046	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	0.2222
p.R648C	TCGA-DF-A2KU	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.2222
p.D648E	DO229037	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.2222
p.S661F	DO26210	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.R644C	SIDM01174	Cervical Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1111
p.R644C	ACH-001402	Cervical Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.1111
p.R644C	SW756	cervix	COSMIC	ASSST	DEG_SPOP_SBC_1	0.1111
p.A643D	DO228974	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.0833
p.D665G	DO41379	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 17 of 17 entries

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Drug responses associated with ARHGEF11 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ASSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37088	Amiloride-sensitive sodium channel subunit alpha	DEG_SPOP_SBC_1	659:663	ASSST	SPOP	0.9733	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	695:699	ASSST	SPOP	0.9867	More...
Q9BXK5	Bcl-2-like protein 13	DEG_SPOP_SBC_1	2:6	ASSST	SPOP	0.8664	More...
A1A5D9	BICD family-like cargo adapter 2	DEG_SPOP_SBC_1	476:480	ASSST	SPOP	0.8186	More...
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SPOP_SBC_1	242:246	ASSST	SPOP	0.9387	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	921:925	ASSST	SPOP	0.9124	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	127:131	ASSST	SPOP	0.9877	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	3090:3094	ASSST	SPOP	0.9844	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	292:296	ASSST	SPOP	0.9783	More...
O43719	HIV Tat-specific factor 1	DEG_SPOP_SBC_1	82:86	ASSST	SPOP	0.9934	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	590:594	ASSST	SPOP	0.6205	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	367:371	ASSST	SPOP	0.9994	More...
Q9Y561	Low-density lipoprotein receptor-related protein 12	DEG_SPOP_SBC_1	693:697	ASSST	SPOP	0.9867	More...
P43363	Melanoma-associated antigen 10	DEG_SPOP_SBC_1	38:42	ASSST	SPOP	0.9727	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1610:1614	ASSST	SPOP	0.9923	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2846:2850	ASSST	SPOP	0.9874	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	760:764	ASSST	SPOP	0.9801	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	2044:2048	ASSST	SPOP	0.9803	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	22:26	ASSST	SPOP	0.9974	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	43:47	ASSST	SPOP	0.9981	More...
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	DEG_SPOP_SBC_1	359:363	ASSST	SPOP	0.8789	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	847:851	ASSST	SPOP	0.9426	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	755:759	ASSST	SPOP	0.9978	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	144:148	ASSST	SPOP	0.8948	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	312:316	ASSST	SPOP	0.9428	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSST

Degron related mutations and impact score

Drug responses associated with ARHGEF11 mutations

All proteins holding degron of ASSST