DegronMD - Q15735(INPP5J)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V175M	TCGA-06-2565	GBM	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.V175M	TCGA-C5-A7CJ	CESC	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.G87S	TCGA-A5-A0G2	UCEC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6993
p.T66N	TCGA-A8-A09A	BRCA	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R162H	TCGA-AA-3663	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1389
p.R162H	TCGA-AA-A00N	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1389
p.R162H	TCGA-EO-A3B0	UCEC	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1389
p.T58N	TCGA-AJ-A3BH	UCEC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7055
p.A92T	TCGA-AN-A0AK	BRCA	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A92T	TCGA-EE-A3J5	SKCM	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A92T	ACH-000967	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A92T	ACH-001199	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A92T	SNU-C2B	large intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.R399H	TCGA-AP-A059	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.8244
p.R399H	HCC1569	breast	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.8244
p.A32V	TCGA-AU-6004	COAD	TCGA	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.A32V	DO7780	COAD	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.A387V	TCGA-B5-A11Y	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0833
p.V177M	TCGA-BG-A0M7	UCEC	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.V177M	RL95-2	endometrium	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.R178H	TCGA-BR-8487	STAD	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.3056
p.A180T	TCGA-CK-5913	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.25
p.T74I	TCGA-CQ-6222	HNSC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.S53L	TCGA-CV-7104	HNSC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.S53L	DO14798	HNSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.D86N	TCGA-CV-A45W	HNSC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6932
p.D86N	DO52060	HNSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6932
p.D86N	DO228947	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6932
p.P70Q	TCGA-EE-A184	SKCM	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.K172N	TCGA-EE-A3AC	SKCM	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6918
p.G173S	TCGA-FB-AAPQ	PAAD	TCGA	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6993
p.R392H	TCGA-FI-A2EY	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2222
p.R392H	TCGA-G6-A8L8	KIRC	TCGA	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.2222
p.S85R	TCGA-G2-A3VY	BLCA	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7427
p.S20Y	TCGA-QF-A5YS	UCEC	TCGA	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.712
p.S20Y	DO52426	UCEC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.712
p.Y187H	DO228246	BRCA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.0556
p.T67N	DO2955	BRCA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2222
p.L21F	DO222404	BTCA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6981
p.P19A	DO222404	BTCA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7503
p.V176M	DO49886	CESC	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.V176M	DO12730	GBM	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.R46H	DO10276	COAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation substituting flanking lysine	0.1944
p.R46H	DO24120	LUAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation substituting flanking lysine	0.1944
p.R46H	SNU-407	large intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation substituting flanking lysine	0.1944
p.R100G	DO7780	COAD	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.E169G	DO230311	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6087
p.R163C	DO227987	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1667
p.V178M	DO222765	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.3056
p.V178M	DO42089	UCEC	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.3056
p.V178M	RL95-2	endometrium	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.3056
p.T99I	DO222849	COCA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.P75L	DO233791	GACA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.S172R	DO11166	GBM	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7427
p.T75I	DO14433	HNSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.S208F	DO14158	HNSC	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation altering degron motif	0.7982
p.R63Q	DO20396	KIRC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7329
p.R63Q	DO42977	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7329
p.R15K	DO219232	KIRC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7237
p.E174K	DO228963	LICA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7022
p.A98S	DO228976	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A98S	DO229035	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A190S	DO228978	LICA	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.0556
p.T5S	DO228985	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation substituting flanking lysine	0.1944
p.A53S	DO229015	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.A53S	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.A100S	DO229022	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.G56W	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7825
p.M68I	DO229032	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1944
p.A70S	DO229036	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.R100S	DO229041	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.S10I	DO229006	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.A78S	DO229009	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.L18Q	DO50812	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7765
p.L211S	DO50894	LICA	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.25
p.G184V	DO222358	LICA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1389
p.R15S	DO24596	LUAD	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7427
p.Q69K	DO23624	LUAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1667
p.H73R	DO224563	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0556
p.H73R	DO224563	LUSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.L48P	DO26641	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.G57C	DO45462	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.76
p.K10R	DO27461	LUSC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.P19L	DO220851	MELA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7582
p.G181R	DO222647	MELA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.2222
p.A26T	DO232842	NACA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.G174S	DO218964	PAAD	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6993
p.P199S	DO228014	SKCA	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.3056
p.P60S	DO37535	SKCM	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6752
p.Q203H	DO47278	SKCM	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation altering degron motif	0.7582
p.G94R	DO47268	SKCM	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.L68F	DO37406	SKCM	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1944
p.Q168H	DO47337	SKCM	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.3056
p.E80K	DO37991	SKCM	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.S205L	DO37906	SKCM	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation altering degron motif	0.7667
p.S205L	DO43041	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation altering degron motif	0.7667
p.A28S	DO47623	SKCM	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1667
p.G12E	DO219468	SKCM	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2778
p.F97S	DO51776	STAD	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.A182V	DO229234	THCA	ICGC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1944
p.P48S	DO223282	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.A190V	DO43202	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.0556
p.S59N	DO41235	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7069
p.S81Y	DO41235	UCEC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation blocking phosphorylation signal	0.75
p.G197S	DO41235	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.25
p.G7V	DO41488	UCEC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1389
p.A98T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A98T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A98T	ACH-000995	Leukemia	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A98T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.V174M	SIDM00197	Ewing's Sarcoma	GDSC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7208
p.R65Q	SIDM00410	Other Blood Cancers	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.R65Q	YT	haematopoietic and lymphoid tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.A80V	SIDM00537	Colorectal Carcinoma	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A80V	ACH-000982	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A80V	ACH-001345	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A80V	GP5d	large intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.S409C	SIDM01217	Other Blood Cancers	GDSC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0833
p.S409C	SIDM01463	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0833
p.S409C	ACH-002276	Leukemia	CCLE	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0833
p.S409C	MY-M12	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0833
p.P52S	SIDM01193	Glioma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.P52S	SIDM01768	Melanoma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.P52S	ACH-000040	Brain Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.P52S	ACH-000899	Skin Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.P52S	U-118-MG	central nervous system	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.N171K	ACH-000065	Leukemia	CCLE	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6918
p.N171K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6918
p.R15W	ACH-000622	Brain Cancer	CCLE	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8634
p.G218W	ACH-000945	Lung Cancer	CCLE	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.0556
p.G218W	NCI-H650	lung	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.0556
p.G164S	ACH-000980	Lung Cancer	CCLE	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1944
p.G164S	NCI-H1155	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1944
p.H196Y	ACH-000985	Colon/Colorectal Cancer	CCLE	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.2222
p.H196Y	LS-411N	large intestine	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.2222
p.D72N	ACH-002165	Skin Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0833
p.D72N	ACH-002165	Skin Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.D72N	MZ2-MEL	skin	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0833
p.D72N	MZ2-MEL	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.P7S	SW48	large intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1389
p.G97S	NCI-H1155	lung	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.G165S	NCI-H1155	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.2222
p.R172C	SNU-175	large intestine	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.8301
p.H197Y	LS-411N	large intestine	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.25
p.G14D	COR-L321	NS	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7198
p.K170N	TALL-1	haematopoietic and lymphoid tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6918
p.A25T	SNU-C2B	large intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.P84L	MCC13	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6471
p.S52L	CAMA-1	breast	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.A182S	NCI-H524	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1944
p.A209S	SJRH30	soft tissue	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.3056
p.V62E	SCC-4	upper aerodigestive tract	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7693
p.K52N	HCT-15	large intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.D5N	MZ2-MEL	skin	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation substituting flanking lysine	0.1944
p.R400H	HCC1569	breast	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.8244
p.A93T	SNU-C2B	large intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.D73N	MZ2-MEL	skin	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0556
p.D73N	MZ2-MEL	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.E14K	IPC-298	skin	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7022
p.A31T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.G95W	HEC-1	endometrium	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.A67D	CCK-81	large intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2222
p.R213H	NCI-H1155	lung	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.1944
p.A393T	SNU-C2B	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.25
p.D163N	KM-H2	haematopoietic and lymphoid tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.1667
p.P21A	CS1	bone	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7503
p.Q70L	GP5d	large intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.G55V	MN-60	haematopoietic and lymphoid tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7532
p.A410S	NCI-H2342	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0556
p.Q187H	NCI-H2023	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.0556
p.E214K	IPC-298	skin	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation rewiring degron network	0.1667
p.S65G	OCUM-1	stomach	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.P207S	SW48	large intestine	COSMIC	STPSPVPSP	DEG_COP1_1	200:208	Mutation altering degron motif	0.6752
p.R169T	H513	pleura	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.7876
p.R68M	DU-145	prostate	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1944
p.A181S	NCI-H524	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation rewiring degron network	0.2222
p.G395W	HEC-1	endometrium	COSMIC	PVTTS	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.3056
p.N172K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	169:177	Mutation altering degron motif	0.6918
p.G27W	HEC-1	endometrium	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1944
p.A13V	GP5d	large intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.G94W	HEC-1	endometrium	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5J

UniProt ID: Q15735

Entrez ID: 27124

Protein name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase J)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5J in