DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_SPOP_SBC_1

Location: 396:400

E3 ligase: SPOP

DEGRON score: 0.9907

ASA_SCORE: 64.8

COIL: 0.8414

CONS_SCORE: 0.2996

DSS_SCORE: 0.6141

HELIX: 0.0892

FCONS_SCORE: 1.0836

RIG_SCORE: 0.6474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R399H	TCGA-AP-A059	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.8244
p.R399H	HCC1569	breast	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.8244
p.A387V	TCGA-B5-A11Y	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0833
p.R392H	TCGA-FI-A2EY	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2222
p.R392H	TCGA-G6-A8L8	KIRC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2222
p.S409C	SIDM01217	Other Blood Cancers	GDSC	PVTTS	DEG_SPOP_SBC_1	0.0833
p.S409C	SIDM01463	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.0833
p.S409C	ACH-002276	Leukemia	CCLE	PVTTS	DEG_SPOP_SBC_1	0.0833
p.S409C	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.0833
p.R400H	HCC1569	breast	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.8244
p.A393T	SNU-C2B	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.25
p.A410S	NCI-H2342	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.G395W	HEC-1	endometrium	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of PVTTS