DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3135:3139

E3 ligase: SPOP

DEGRON score: 0.7818

ASA_SCORE: 85.96

COIL: 0.7952

CONS_SCORE: 0.5236

DSS_SCORE: 0.6632

HELIX: 0.015

FCONS_SCORE: 1

RIG_SCORE: 0.66

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3135S	TCGA-A5-A1OF	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.6752
p.P3135S	DO11854	GBM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.6752
p.P3135S	DO42568	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.6752
p.T3138N	TCGA-AP-A1E0	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3138N	TCGA-CZ-5988	KIRC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3138N	DO17462	KIRC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3138N	DO43154	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.S3139Y	TCGA-BS-A0UV	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.712
p.S3139Y	DO42793	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.712
p.S3149F	TCGA-BT-A2LB	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S3149F	DO44098	BLCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S3145C	TCGA-DA-A95Z	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1667
p.S3145C	DO219481	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.L3125F	TCGA-DX-A8BP	SARC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0556
p.L3125F	DO220056	SARC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S3144P	TCGA-E6-A1LX	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S3144P	DO41020	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.D3131N	TCGA-EE-A183	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2222
p.D3131N	DO37715	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.S3149Y	TCGA-EY-A1G8	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S3149Y	DO43578	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S3144L	TCGA-FS-A1Z3	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S3144L	DO37635	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S3144L	SIDM01483	Melanoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S3144L	ACH-000582	Skin Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S3144L	COLO-741	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.P3129H	TCGA-FU-A40J	CESC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1667
p.P3129H	DO44314	CESC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.T3140I	TCGA-GN-A8LK	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T3140I	DO51259	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.H3143N	DO227496	LAML	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143N	DO229060	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.V3130A	DO228960	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.H3143R	DO229060	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143Y	SIDM00216	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143Y	SNU-175	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143Q	SIDM00555	Glioblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143Q	ACH-000631	Brain Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.2222
p.H3143Q	KS-1	central_nervous_system	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.P3129T	SIDM00983	Bladder Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.P3129T	647-V	urinary_tract	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.T3127S	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.T3127S	ACH-000912	Lung Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.1111
p.T3132A	ACH-001664	Gastric Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVTTS