DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2250:2254

E3 ligase: SPOP

DEGRON score: 0.7066

ASA_SCORE: 87.22

COIL: 0.8298

CONS_SCORE: 0.5236

DSS_SCORE: 0.6421

HELIX: 0.0158

FCONS_SCORE: 1

RIG_SCORE: 0.694

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2255I	TCGA-AN-A046	BRCA	TCGA	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255I	DO1285	BRCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.S2259L	TCGA-GN-A26C	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S2259L	DO37782	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S2254F	TCGA-UY-A8OD	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	0.7982
p.S2254F	DO219039	BLCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7982
p.A2257D	TCGA-VS-A9UA	CESC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.25
p.A2257D	DO219730	CESC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.25
p.A2257V	DO49675	LIAD	ICGC	PVTTS	DEG_SPOP_SBC_1	0.25
p.A2257V	DO22802	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.25
p.T2258S	DO228960	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.T2258S	DO228998	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.T2258S	DO229056	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.T2258I	DO220891	MELA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.A2264V	DO232761	PBCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.T2255A	SIDM00435	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00434	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00373	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00611	Kidney Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01175	Other Sarcomas	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00993	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01036	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01005	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00569	Osteosarcoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00350	Head and Neck Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00955	Melanoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00391	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00259	Neuroblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00085	Glioma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00276	Biliary Tract Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00672	Hepatocellular Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00049	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00476	Ovarian Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00997	Thyroid Gland Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00794	Other Solid Cancers	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00574	Glioblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01191	Osteosarcoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01074	Glioblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM00273	Glioblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.T2255A	SIDM01690	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVTTS