DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3370:3374

E3 ligase: SPOP

DEGRON score: 0.9693

ASA_SCORE: 84.86

COIL: 0.8114

CONS_SCORE: 0.5236

DSS_SCORE: 0.6282

HELIX: 0.0144

FCONS_SCORE: 1

RIG_SCORE: 0.7056

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3363N	TCGA-A6-5665	COAD	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1389
p.T3363N	DO9756	COAD	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.D3366N	TCGA-DF-A2KN	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2222
p.D3366N	DO223282	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.S3378N	TCGA-FI-A2F4	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2222
p.S3378N	DO43434	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2222
p.S3361F	TCGA-FR-A726	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0833
p.S3361F	DO48665	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0833
p.T3382K	DO228508	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.L3379S	DO229052	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.T3373N	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00074	Burkitt's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01123	Prostate Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00521	Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01020	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00884	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00113	Kidney Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00602	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01199	Hepatocellular Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00099	Mesothelioma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00660	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00040	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00194	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00260	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00687	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00694	Other Solid Cancers	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00963	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00910	Neuroblastoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00888	Other Solid Cancers	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00883	Non-Cancerous	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00837	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00280	Gastric Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00397	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00097	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00428	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00261	Ewing's Sarcoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00628	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01609	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01624	Bladder Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01608	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01578	Bladder Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00008	Ovarian Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM00170	Head and Neck Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01409	Bladder Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01776	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01435	Hepatocellular Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01690	Plasma Cell Myeloma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01696	Mesothelioma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.T3373N	SIDM01254	Burkitt's Lymphoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7055
p.P3370H	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.7694
p.P3370H	ACH-000826	Lung Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.7694
p.P3370H	CAL-12T	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.7694
p.P3381H	SIDM00150	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.P3381H	ACH-000969	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.1389
p.P3381H	KM12	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.S3374Y	SIDM01588	Endometrial Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.712
p.S3374Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVTTS