DegronMD - P42858(HTT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2641K	TCGA-56-A4BW	LUSC	TCGA	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1111
p.E2641K	DO45441	LUSC	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1111
p.S576L	TCGA-78-7155	LUAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation altering degron motif	0.6556
p.S576L	DO23590	LUAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation altering degron motif	0.6556
p.Q563H	TCGA-A5-A0G2	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.Q563H	DO41235	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.G585S	TCGA-A5-A0G2	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1389
p.G585S	DO41235	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1389
p.N588K	TCGA-AA-3811	COAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.N588K	TCGA-CV-7255	HNSC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.N588K	DO7962	COAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.N588K	DO14718	HNSC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0556
p.A572T	TCGA-AJ-A3BH	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.3056
p.A572T	DO41638	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.3056
p.D587N	TCGA-AP-A1DV	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0833
p.D587N	DO43186	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.0833
p.S1210Y	TCGA-BR-4280	STAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation blocking phosphorylation signal	0.5556
p.S1210Y	DO38663	STAD	ICGC	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation blocking phosphorylation signal	0.5556
p.S1224T	TCGA-BR-4370	STAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.2778
p.S1224T	DO38499	STAD	ICGC	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.2778
p.W2623L	TCGA-DD-A113	LIHC	TCGA	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1944
p.W2623L	DO229027	LICA	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1944
p.W2623L	DO22920	LIHC	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1944
p.N2626D	TCGA-EC-A1NJ	UCEC	TCGA	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.2778
p.N2626D	DO227688	SKCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.2778
p.N2626D	DO40855	UCEC	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.2778
p.E567K	TCGA-FF-8042	DLBC	TCGA	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1667
p.E567K	DO222306	DLBC	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1667
p.E567K	ACH-001970	Metastasis	CCLE	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1667
p.S1224F	TCGA-FS-A1ZF	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.2778
p.S1224F	DO38039	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.2778
p.H2620N	TCGA-XF-A9T6	BLCA	TCGA	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1111
p.H2620N	DO51926	BLCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1111
p.E2633Q	DO222953	BTCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation altering degron motif	0.6744
p.T586I	DO222769	COCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.1111
p.P569H	DO233915	GACA	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.2222
p.S2627N	DO23146	LINC	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.3056
p.S2627N	DO45071	LINC	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.3056
p.P569S	DO232224	PBCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	573:578	Mutation rewiring degron network	0.2222
p.E2638V	DO229211	THCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation rewiring degron network	0.1944
p.R1211G	SIDM00731	Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.1389
p.R1211G	ACH-000399	Lung Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.1389
p.R1211G	NCI-H2196	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	1218:1222	Mutation rewiring degron network	0.1389
p.P2630T	SIDM01196	Hepatocellular Carcinoma	GDSC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation altering degron motif	0.7031
p.P2630T	ACH-000422	Liver Cancer	CCLE	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation altering degron motif	0.7031
p.P2630T	SNU-475	liver	COSMIC	ITPLRE	DEG_SCF_FBW7_2	2628:2633	Mutation altering degron motif	0.7031

Kaplan plot for HTT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HTT

UniProt ID: P42858

Entrez ID: 3064

Protein name: Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HTT in