DegronMD

Uniprot ID: P42858

Source protein: Huntingtin

Source gene: HTT

Class: DEG_SCF_FBW7_1

Location: 573:578

E3 ligase: FBXW7

DEGRON score: 0.8979

ASA_SCORE: 77.9167

COIL: 0.8973

CONS_SCORE: 0.3074

DSS_SCORE: 0.735

HELIX: 0.063

FCONS_SCORE: 0.9527

RIG_SCORE: 0.642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S576L	TCGA-78-7155	LUAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.6556
p.S576L	DO23590	LUAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.6556
p.Q563H	TCGA-A5-A0G2	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.Q563H	DO41235	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.G585S	TCGA-A5-A0G2	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.1389
p.G585S	DO41235	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.1389
p.N588K	TCGA-AA-3811	COAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.N588K	TCGA-CV-7255	HNSC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.N588K	DO7962	COAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.N588K	DO14718	HNSC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.0556
p.A572T	TCGA-AJ-A3BH	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.A572T	DO41638	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.D587N	TCGA-AP-A1DV	UCEC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.0833
p.D587N	DO43186	UCEC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.0833
p.E567K	TCGA-FF-8042	DLBC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.1667
p.E567K	DO222306	DLBC	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.1667
p.E567K	ACH-001970	Metastasis	CCLE	VTPSDS	DEG_SCF_FBW7_1	0.1667
p.T586I	DO222769	COCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.1111
p.P569H	DO233915	GACA	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.2222
p.P569S	DO232224	PBCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_1	2245:2250	VTPSDS	FBXW7	0.9379	More...
P42858	Huntingtin	DEG_SCF_FBW7_1	573:578	VTPSDS	FBXW7	0.8979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons