DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SCF_FBW7_1

Location: 2245:2250

E3 ligase: FBXW7

DEGRON score: 0.9379

ASA_SCORE: 84.6

COIL: 0.9468

CONS_SCORE: 0.4939

DSS_SCORE: 0.8019

HELIX: 0.0212

FCONS_SCORE: 0.9112

RIG_SCORE: 0.608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2248A	TCGA-19-1386	GBM	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.7588
p.G2251R	TCGA-55-8094	LUAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.G2251R	SIDM01187	Breast Carcinoma	GDSC	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.P2247T	TCGA-BF-A1Q0	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.7031
p.P2247T	TCGA-EE-A17Z	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.7031
p.P2247T	TCGA-EE-A2GO	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.7031
p.G2243E	TCGA-CV-A6K2	HNSC	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.2778
p.T2246A	TCGA-HU-8602	STAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	0.825
p.L2254R	DO7776	COAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.2222
p.M2259I	DO218863	SKCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.1944
p.M2259I	DO37410	SKCM	ICGC	VTPSDS	DEG_SCF_FBW7_1	0.1944
p.G2251W	SIDM01099	Neuroblastoma	GDSC	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.G2251W	SK-N-FI	autonomic_ganglia	COSMIC	VTPSDS	DEG_SCF_FBW7_1	0.3056
p.G2255W	SK-N-FI	autonomic_ganglia	COSMIC	VTPSDS	DEG_SCF_FBW7_1	0.1944
p.P2238L	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSDS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_1	2245:2250	VTPSDS	FBXW7	0.9379	More...
P42858	Huntingtin	DEG_SCF_FBW7_1	573:578	VTPSDS	FBXW7	0.8979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons