DegronMD

Uniprot ID: P42858

Source protein: Huntingtin

Source gene: HTT

Class: DEG_SCF_FBW7_2

Location: 2628:2633

E3 ligase: FBXW7

DEGRON score: 0.9871

ASA_SCORE: 77.9

COIL: 0.7402

CONS_SCORE: 0.3263

DSS_SCORE: 0.4858

HELIX: 0.2227

FCONS_SCORE: 0.9995

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2641K	TCGA-56-A4BW	LUSC	TCGA	ITPLRE	DEG_SCF_FBW7_2	0.1111
p.E2641K	DO45441	LUSC	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.1111
p.W2623L	TCGA-DD-A113	LIHC	TCGA	ITPLRE	DEG_SCF_FBW7_2	0.1944
p.W2623L	DO229027	LICA	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.1944
p.W2623L	DO22920	LIHC	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.1944
p.N2626D	TCGA-EC-A1NJ	UCEC	TCGA	ITPLRE	DEG_SCF_FBW7_2	0.2778
p.N2626D	DO227688	SKCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.2778
p.N2626D	DO40855	UCEC	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.2778
p.H2620N	TCGA-XF-A9T6	BLCA	TCGA	ITPLRE	DEG_SCF_FBW7_2	0.1111
p.H2620N	DO51926	BLCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.1111
p.E2633Q	DO222953	BTCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.6744
p.S2627N	DO23146	LINC	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.3056
p.S2627N	DO45071	LINC	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.3056
p.E2638V	DO229211	THCA	ICGC	ITPLRE	DEG_SCF_FBW7_2	0.1944
p.P2630T	SIDM01196	Hepatocellular Carcinoma	GDSC	ITPLRE	DEG_SCF_FBW7_2	0.7031
p.P2630T	ACH-000422	Liver Cancer	CCLE	ITPLRE	DEG_SCF_FBW7_2	0.7031
p.P2630T	SNU-475	liver	COSMIC	ITPLRE	DEG_SCF_FBW7_2	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42858	Huntingtin	DEG_SCF_FBW7_2	2628:2633	ITPLRE	FBXW7	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons