DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10028:10032

E3 ligase: SPOP

DEGRON score: 0.5276

ASA_SCORE: 87.16

COIL: 0.8672

CONS_SCORE: 0

DSS_SCORE: 0.3651

HELIX: 0.0092

FCONS_SCORE: 0

RIG_SCORE: 0.6881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10023Y	TCGA-AP-A1DV	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023Y	DO43186	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.T10030A	TCGA-BS-A0UJ	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.7139
p.T10030A	DO42745	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7139
p.P10028S	TCGA-IH-A3EA	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.6752
p.P10028S	DO37667	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.6752
p.S10023F	TCGA-RP-A693	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023F	DO51268	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023F	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023F	COLO-680N	oesophagus	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10020F	DO225198	BRCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.T10030K	DO229016	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7306
p.P10040L	DO234262	ESAD	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.P10040L	SIDM00683	Prostate Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.P10040L	SIDM00839	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.P10040L	LoVo	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.P10040L	LNCaP-Clone-FGC	prostate	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.S10034F	DO220851	MELA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.S10042I	SIDM01062	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S10042I	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S10042I	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S10042I	HDQ-P1	breast	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.S10023C	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023C	ACH-000544	Esophageal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.1944
p.S10023C	OE21	oesophagus	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PVTTS