DegronMD - Q9NR99(MXRA5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1280K	TCGA-06-0745	GBM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1667
p.R1280K	DO12034	GBM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1667
p.R1266I	TCGA-06-5416	GBM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.2778
p.R1266I	DO10880	GBM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.2778
p.T880K	TCGA-19-1389	GBM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.6195
p.T880K	DO12382	GBM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.6195
p.K1191N	TCGA-19-5956	GBM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.2778
p.K1191N	DO13863	GBM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.2778
p.P877A	TCGA-23-1110	OV	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.2778
p.P877A	DO29398	OV	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.2778
p.Y2398S	TCGA-28-1760	GBM	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation altering degron motif	0.712
p.Y2398S	DO13725	GBM	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation altering degron motif	0.712
p.Q1195K	TCGA-49-4488	LUAD	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.5833
p.Q1195K	DO24750	LUAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.5833
p.D1461H	TCGA-55-7907	LUAD	TCGA	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.2778
p.D1461H	DO25396	LUAD	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.2778
p.R1133K	TCGA-55-A490	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2222
p.R1133K	DO24596	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2222
p.K992E	TCGA-56-8305	LUSC	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation substituting flanking lysine	0.1944
p.K992E	DO223725	LUSC	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation substituting flanking lysine	0.1944
p.A1485S	TCGA-56-8307	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1667
p.A1485S	DO219139	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1667
p.L1460I	TCGA-62-A46R	LUAD	TCGA	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.3056
p.L1460I	TCGA-BQ-7059	KIRP	TCGA	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.3056
p.L1460I	DO20932	KIRP	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.3056
p.L1460I	DO45355	LUAD	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.3056
p.P1138Q	TCGA-95-7043	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.5924
p.P1138Q	TCGA-EE-A29E	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.5924
p.P1138Q	DO24739	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.5924
p.P1138Q	DO37831	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.5924
p.S1495Y	TCGA-97-A4LX	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.712
p.S1495Y	DO218934	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.712
p.P1483H	TCGA-99-7458	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1111
p.P1483H	DO25416	LUAD	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1111
p.A1492G	TCGA-A2-A25B	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.6429
p.A1492G	DO2706	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.6429
p.V1009G	TCGA-AA-3684	COAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.25
p.V1009G	DO8802	COAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.25
p.Q1134K	TCGA-AA-A02Y	COAD	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.Q1134K	DO7858	COAD	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.S1272N	TCGA-AB-2808	LAML	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation altering degron motif	0.5958
p.S1272N	DO21487	LAML	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation altering degron motif	0.5958
p.D1207N	TCGA-AC-A23H	BRCA	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.25
p.D1207N	DO2401	BRCA	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.25
p.D889N	TCGA-AC-A5XS	BRCA	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.25
p.D889N	DO50023	BRCA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.25
p.T1801S	TCGA-AC-A6IW	BRCA	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.1944
p.T1801S	DO50028	BRCA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.1944
p.L1277I	TCGA-AP-A1E0	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.25
p.L1277I	DO43154	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.25
p.S1199Y	TCGA-AX-A0J0	UCEC	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6009
p.S1199Y	DO41133	UCEC	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6009
p.S1283Y	TCGA-B5-A1MR	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.0833
p.S1283Y	DO41758	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.0833
p.A2408D	TCGA-B5-A3FA	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408D	TCGA-B5-A3FA	UCEC	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.A2408D	DO52402	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408D	DO52402	UCEC	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.P1785S	TCGA-BH-A0H5	BRCA	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.2222
p.P1785S	DO5207	BRCA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.2222
p.G2401D	TCGA-BR-6452	STAD	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.3056
p.G2401D	DO38404	STAD	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.3056
p.R1517I	TCGA-BS-A0UF	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.1111
p.R1517I	DO41488	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.1111
p.E2426K	TCGA-C5-A1BL	CESC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.0833
p.E2426K	DO48986	CESC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.0833
p.S1273P	TCGA-CA-6717	COAD	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation altering degron motif	0.5641
p.S1273P	DO8264	COAD	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation altering degron motif	0.5641
p.R1149M	TCGA-CC-A7IK	LIHC	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1111
p.R1149M	DO52184	LIHC	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1111
p.W1205L	TCGA-D3-A1QA	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.3056
p.W1205L	DO47469	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.3056
p.P1005S	TCGA-D3-A2J8	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5641
p.P1005S	TCGA-EE-A2M5	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5641
p.P1005S	DO222423	MELA	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5641
p.P1005S	DO37778	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5641
p.P1005S	DO37425	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5641
p.G1797E	TCGA-D3-A51G	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1797E	DO47700	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1797R	TCGA-D3-A51G	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1797R	TCGA-HT-7471	LGG	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1797R	DO22345	LGG	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1797R	DO47700	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.P1261L	TCGA-D3-A51J	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1389
p.P1261L	DO47359	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1389
p.P1261S	TCGA-D3-A51J	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1389
p.P1261S	DO47359	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1389
p.P1151L	TCGA-D3-A8GL	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0556
p.P1151L	DO50287	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0556
p.S2411F	TCGA-D3-A8GO	SKCM	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation blocking phosphorylation signal	0.75
p.S2411F	DO51242	SKCM	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation blocking phosphorylation signal	0.75
p.A2408S	TCGA-D5-6530	COAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408S	TCGA-D5-6530	COAD	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.A2408S	TCGA-FP-7829	STAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408S	TCGA-FP-7829	STAD	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.A2408S	DO8312	COAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408S	DO8312	COAD	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.A2408S	DO38308	STAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408S	DO38308	STAD	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.E1538K	TCGA-D9-A1JW	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.0833
p.E1538K	DO37786	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.0833
p.P1793L	TCGA-DA-A1HY	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation altering degron motif	0.7582
p.P1793L	TCGA-DU-6392	LGG	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation altering degron motif	0.7582
p.P1793L	DO22237	LGG	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation altering degron motif	0.7582
p.P1793L	DO37409	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation altering degron motif	0.7582
p.P1003Q	TCGA-DA-A1I4	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.7035
p.P1003Q	DO37655	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.7035
p.T1459I	TCGA-DK-A1A3	BLCA	TCGA	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.T1459I	DO558	BLCA	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.T1459I	SIDM01658	Unknown	GDSC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.T1459I	SIDM01413	Oral Cavity Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.T1459I	ACH-000598	Myeloma	CCLE	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.T1459I	ACH-000630	Head and Neck Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.7078
p.Q2406R	TCGA-E9-A249	BRCA	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.1667
p.Q2406R	TCGA-E9-A249	BRCA	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1667
p.Q2406R	DO3856	BRCA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.1667
p.Q2406R	DO3856	BRCA	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1667
p.M1488I	TCGA-EB-A5UL	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.M1488I	DO47601	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.S1199F	TCGA-EB-A5UM	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6871
p.S1199F	DO47282	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6871
p.L1001P	TCGA-EE-A29E	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.6471
p.L1001P	DO37831	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.6471
p.N1532K	TCGA-EE-A2GO	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.25
p.N1532K	DO37823	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.25
p.D890N	TCGA-EE-A2MS	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.2222
p.D890N	DO37567	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.2222
p.R1390S	TCGA-EE-A3AC	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1667
p.R1390S	DO37631	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1667
p.P1202S	TCGA-EE-A3J5	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6752
p.P1202S	DO47331	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6752
p.R2410C	TCGA-EO-A3L0	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2778
p.R2410C	TCGA-EO-A3L0	UCEC	TCGA	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.0556
p.R2410C	DO219775	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2778
p.R2410C	DO219775	UCEC	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.0556
p.V1136I	TCGA-ER-A194	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.3056
p.V1136I	DO47646	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.3056
p.S1494L	TCGA-ER-A19F	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.7667
p.S1494L	DO37679	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.7667
p.S1494L	SIDM01753	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.7667
p.S1494L	ACH-000239	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation altering degron motif	0.7667
p.R1280I	TCGA-EY-A1GI	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1667
p.R1280I	DO41211	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.1667
p.P1788L	TCGA-EY-A548	UCEC	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.P1788L	DO220857	MELA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.P1788L	DO48173	UCEC	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.3056
p.G1389R	TCGA-FD-A3SO	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1389
p.G1389R	DO569	BLCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1389
p.E886K	TCGA-FR-A8YC	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	TCGA-FS-A1ZW	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	TCGA-OD-A75X	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	DO220895	MELA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	DO37519	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	DO50301	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.E886K	DO48601	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.7022
p.P1188H	TCGA-FS-A1ZB	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.1944
p.P1188H	DO37886	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.1944
p.E1402K	TCGA-FS-A1ZK	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.E1402K	DO37474	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.E1402K	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.E1402K	ACH-000922	Leukemia	CCLE	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.E1402K	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.N1267D	TCGA-G4-6588	COAD	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.3056
p.N1267D	DO10140	COAD	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.3056
p.S1515C	TCGA-HU-A4GF	STAD	TCGA	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.0556
p.S1515C	DO47885	STAD	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.0556
p.L874I	TCGA-IB-7651	PAAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874I	DO46657	PAAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874I	SIDM00193	Colorectal Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874I	ACH-000991	Colon/Colorectal Cancer	CCLE	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874I	SNU-81	large intestine	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.S1193P	TCGA-J2-A4AD	LUAD	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6752
p.S1193P	DO23915	LUAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.6752
p.G1401V	TCGA-L9-A8F4	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401V	DO49876	LUAD	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.E893K	TCGA-MN-A4N4	LUAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1389
p.E893K	DO26250	LUAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1389
p.S1143T	TCGA-OR-A5L5	ACC	TCGA	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2778
p.A1386T	TCGA-QF-A5YS	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.0556
p.A1386T	DO52426	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.0556
p.T1498K	TCGA-RG-A7D4	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.T1498K	DO52316	LIHC	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.T1498K	DO45119	LIRI	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.L874F	TCGA-RP-A695	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874F	DO51270	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.R1487Q	TCGA-SL-A6J9	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.2222
p.R1487Q	DO219786	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.2222
p.L884P	TCGA-VQ-A924	STAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.6471
p.L884P	DO51795	STAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation altering degron motif	0.6471
p.S1519F	TCGA-W3-A825	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.1667
p.S1519F	DO51272	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.1667
p.M993I	TCGA-W3-A825	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.1111
p.M993I	DO51272	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.1111
p.S1193L	TCGA-W3-AA1V	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.7667
p.S1193L	DO51276	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.7667
p.P1259L	TCGA-Z2-A8RT	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.0833
p.P1259L	DO51301	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.0833
p.P1005T	TCGA-ZG-A9NI	PRAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5919
p.P1005T	DO219448	PRAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation altering degron motif	0.5919
p.P1213L	DO222576	COCA	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.0833
p.G1394D	DO229010	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO229013	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO229016	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO229003	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO229005	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO229489	LAML	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.G1394D	DO230550	LUSC	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.A1128V	DO229010	COCA	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.A1128V	DO229003	COCA	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.A1128V	DO231031	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.A1128V	DO231049	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.A1128V	DO231209	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.E1197D	DO50343	ESAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation altering degron motif	0.5647
p.A1786T	DO233058	GACA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.25
p.P1407S	DO233865	GACA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1389
p.Q1520E	DO229493	LAML	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.1944
p.L1790W	DO231963	LICA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation altering degron motif	0.5904
p.A2408T	DO228559	LICA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2222
p.A2408T	DO228559	LICA	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.1111
p.C2418Y	DO228835	LICA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.3056
p.S892Y	DO229028	LICA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1667
p.S1258R	DO229045	LICA	ICGC	IVTPSSE	DEG_SCF_FBW7_2	1268:1274	Mutation rewiring degron network	0.0556
p.K1489T	DO50862	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.2778
p.L2404F	DO48682	LIRI	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.1111
p.L2404F	DO48682	LIRI	ICGC	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation rewiring degron network	0.2222
p.E1456K	DO220866	MELA	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation altering degron motif	0.591
p.E1402G	DO222396	MELA	ICGC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2778
p.L2419W	DO222409	MELA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation rewiring degron network	0.2778
p.E1527K	DO222714	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation altering degron motif	0.7022
p.E1527K	DO229446	SKCA	ICGC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation altering degron motif	0.7022
p.E1466Q	DO27879	ORCA	ICGC	AETTT	DEG_SPOP_SBC_1	1455:1459	Mutation rewiring degron network	0.1389
p.R1133G	DO232011	ORCA	ICGC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2222
p.G1783R	DO46473	OV	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.1667
p.A1486V	SIDM00484	Thyroid Gland Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1944
p.A1486V	SIDM00280	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1944
p.A1486V	ACH-000560	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1944
p.A1486V	ACH-001321	Thyroid Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1944
p.A1486V	ECC10	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1944
p.L874P	SIDM00437	Acute Myeloid Leukemia	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	SIDM00572	Gastric Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	SIDM00240	Cervical Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	SIDM00618	Hepatocellular Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	SIDM01551	Gastric Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	SIDM01472	Hepatocellular Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	JHH-1	liver	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	OMC-1	cervix	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L874P	NUGC-3	stomach	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.1944
p.L1780R	SIDM00329	Hodgkin's Lymphoma	GDSC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.0833
p.L1780R	ACH-000806	Lymphoma	CCLE	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.0833
p.L1780R	L-540	haematopoietic and lymphoid tissue	COSMIC	LLHTPQTT	DEG_SCF_FBW7_1	1789:1796	Mutation rewiring degron network	0.0833
p.T1484A	SIDM00529	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.1389
p.Y1533C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.2222
p.Y1533C	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.2222
p.M1488K	SIDM00094	Kidney Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.M1488K	ACH-002199	Kidney Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.M1488K	SN12C	kidney	COSMIC	PASSS	DEG_SPOP_SBC_1	1491:1495	Mutation rewiring degron network	0.25
p.D1189N	SIDM00704	Small Cell Lung Carcinoma	GDSC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.2222
p.D1189N	ACH-000639	Lung Cancer	CCLE	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.2222
p.D1189N	NCI-H211	lung	COSMIC	SSQVESSLVPTA	DEG_COP1_1	1193:1204	Mutation rewiring degron network	0.2222
p.S1147F	SIDM00035	Thyroid Gland Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1147F	ACH-000037	Sarcoma	CCLE	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1147F	S-117	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.G1401E	SIDM00527	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401E	ACH-000935	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401E	MDST8	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401R	SIDM00527	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401R	ACH-000935	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.G1401R	MDST8	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.Q1134L	SIDM00126	Melanoma	GDSC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.Q1134L	ACH-002147	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.Q1134L	K2	skin	COSMIC	APSST	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.G2414V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation altering degron motif	0.7532
p.G2414V	ACH-001638	Lymphoma	CCLE	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation altering degron motif	0.7532
p.G2414V	RC-K8	haematopoietic and lymphoid tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation altering degron motif	0.7532
p.Y2416H	SIDM01608	Endometrial Carcinoma	GDSC	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation altering degron motif	0.7229
p.Y2416H	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGNYT	DEG_SCF_TRCP1_1	2412:2417	Mutation altering degron motif	0.7229
p.F1530L	SIDM01577	Plasma Cell Myeloma	GDSC	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.3056
p.F1530L	ACH-000889	Myeloma	CCLE	SKENV	DEG_APCC_KENBOX_2	1525:1529	Mutation rewiring degron network	0.3056
p.E876K	SIDM01473	Plasma Cell Myeloma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.25
p.E876K	ACH-000541	Myeloma	CCLE	VTSTPLEE	DEG_SCF_FBW7_2	879:886	Mutation rewiring degron network	0.25
p.Y2398H	ACH-000791	Lung Cancer	CCLE	KYQIYQD	LIG_APCC_ABBAyCdc20_2	2394:2400	Mutation altering degron motif	0.6118
p.I1007V	ACH-001030	Bone Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.3056
p.V1009L	ACH-001649	Prostate Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	1001:1006	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MXRA5

UniProt ID: Q9NR99

Entrez ID: 25878

Protein name: Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MXRA5 in