DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SCF_FBW7_2

Location: 879:886

E3 ligase: FBXW7

DEGRON score: 0.7228

ASA_SCORE: 77.3875

COIL: 0.581

CONS_SCORE: 0.3401

DSS_SCORE: 0.5341

HELIX: 0.0759

FCONS_SCORE: 1.171

RIG_SCORE: 0.7613

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T880K	TCGA-19-1389	GBM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.6195
p.T880K	DO12382	GBM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.6195
p.P877A	TCGA-23-1110	OV	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.2778
p.P877A	DO29398	OV	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.2778
p.D889N	TCGA-AC-A5XS	BRCA	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.25
p.D889N	DO50023	BRCA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.25
p.D890N	TCGA-EE-A2MS	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.2222
p.D890N	DO37567	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.2222
p.E886K	TCGA-FR-A8YC	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	TCGA-FS-A1ZW	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	TCGA-OD-A75X	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	DO220895	MELA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	DO37519	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	DO50301	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.E886K	DO48601	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.7022
p.L874I	TCGA-IB-7651	PAAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874I	DO46657	PAAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874I	SIDM00193	Colorectal Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874I	ACH-000991	Colon/Colorectal Cancer	CCLE	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874I	SNU-81	large_intestine	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.E893K	TCGA-MN-A4N4	LUAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.1389
p.E893K	DO26250	LUAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.1389
p.L874F	TCGA-RP-A695	SKCM	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874F	DO51270	SKCM	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L884P	TCGA-VQ-A924	STAD	TCGA	VTSTPLEE	DEG_SCF_FBW7_2	0.6471
p.L884P	DO51795	STAD	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.6471
p.S892Y	DO229028	LICA	ICGC	VTSTPLEE	DEG_SCF_FBW7_2	0.1667
p.L874P	SIDM00437	Acute Myeloid Leukemia	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	SIDM00572	Gastric Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	SIDM00240	Cervical Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	SIDM00618	Hepatocellular Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	SIDM01551	Gastric Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	SIDM01472	Hepatocellular Carcinoma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	JHH-1	liver	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	OMC-1	cervix	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.L874P	NUGC-3	stomach	COSMIC	VTSTPLEE	DEG_SCF_FBW7_2	0.1944
p.E876K	SIDM01473	Plasma Cell Myeloma	GDSC	VTSTPLEE	DEG_SCF_FBW7_2	0.25
p.E876K	ACH-000541	Myeloma	CCLE	VTSTPLEE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTPLEE

Degron related mutations and impact score

Drug responses associated with MXRA5 mutations

All proteins holding degron of VTSTPLEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_FBW7_2	879:886	VTSTPLEE	FBXW7	0.7228	More...