DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SCF_FBW7_1

Location: 1789:1796

E3 ligase: FBXW7

DEGRON score: 0.7062

ASA_SCORE: 58.1375

COIL: 0.4449

CONS_SCORE: 0.3735

DSS_SCORE: 0.6888

HELIX: 0.0081

FCONS_SCORE: 1.1199

RIG_SCORE: 0.6548

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1801S	TCGA-AC-A6IW	BRCA	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.1944
p.T1801S	DO50028	BRCA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.1944
p.P1785S	TCGA-BH-A0H5	BRCA	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.2222
p.P1785S	DO5207	BRCA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.2222
p.G1797E	TCGA-D3-A51G	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.G1797E	DO47700	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.G1797R	TCGA-D3-A51G	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.G1797R	TCGA-HT-7471	LGG	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.G1797R	DO22345	LGG	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.G1797R	DO47700	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.P1793L	TCGA-DA-A1HY	SKCM	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.7582
p.P1793L	TCGA-DU-6392	LGG	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.7582
p.P1793L	DO22237	LGG	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.7582
p.P1793L	DO37409	SKCM	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.7582
p.P1788L	TCGA-EY-A548	UCEC	TCGA	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.P1788L	DO220857	MELA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.P1788L	DO48173	UCEC	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.3056
p.A1786T	DO233058	GACA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.25
p.L1790W	DO231963	LICA	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.5904
p.G1783R	DO46473	OV	ICGC	LLHTPQTT	DEG_SCF_FBW7_1	0.1667
p.L1780R	SIDM00329	Hodgkin's Lymphoma	GDSC	LLHTPQTT	DEG_SCF_FBW7_1	0.0833
p.L1780R	ACH-000806	Lymphoma	CCLE	LLHTPQTT	DEG_SCF_FBW7_1	0.0833
p.L1780R	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	LLHTPQTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_FBW7_1	1789:1796	LLHTPQTT	FBXW7	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons