DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SCF_TRCP1_1

Location: 2412:2417

E3 ligase: BTRC

DEGRON score: 0.7685

ASA_SCORE: 31.2667

COIL: 0.1745

CONS_SCORE: 0.561

DSS_SCORE: 0.3537

HELIX: 0.1502

FCONS_SCORE: 1.2087

RIG_SCORE: 0.7494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2408D	TCGA-B5-A3FA	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.A2408D	DO52402	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.E2426K	TCGA-C5-A1BL	CESC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.0833
p.E2426K	DO48986	CESC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.0833
p.S2411F	TCGA-D3-A8GO	SKCM	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.75
p.S2411F	DO51242	SKCM	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.75
p.A2408S	TCGA-D5-6530	COAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.A2408S	TCGA-FP-7829	STAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.A2408S	DO8312	COAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.A2408S	DO38308	STAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.Q2406R	TCGA-E9-A249	BRCA	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.1667
p.Q2406R	DO3856	BRCA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1667
p.R2410C	TCGA-EO-A3L0	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2778
p.R2410C	DO219775	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2778
p.A2408T	DO228559	LICA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.C2418Y	DO228835	LICA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.3056
p.L2404F	DO48682	LIRI	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1111
p.L2419W	DO222409	MELA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2778
p.G2414V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGNYT	DEG_SCF_TRCP1_1	0.7532
p.G2414V	ACH-001638	Lymphoma	CCLE	DSGNYT	DEG_SCF_TRCP1_1	0.7532
p.G2414V	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.7532
p.Y2416H	SIDM01608	Endometrial Carcinoma	GDSC	DSGNYT	DEG_SCF_TRCP1_1	0.7229
p.Y2416H	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGNYT	DEG_SCF_TRCP1_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXZ4	Netrin receptor UNC5D	DEG_SCF_TRCP1_1	225:230	DSGNYT	BTRC	0.9083	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_TRCP1_1	2412:2417	DSGNYT	BTRC	0.7685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons