DegronMD

Uniprot ID: Q6UXZ4

Source protein: Netrin receptor UNC5D

Source gene: UNC5D

Class: DEG_SCF_TRCP1_1

Location: 225:230

E3 ligase: BTRC

DEGRON score: 0.9083

ASA_SCORE: 69.25

COIL: 0.7827

CONS_SCORE: 0.7004

DSS_SCORE: 0.1795

HELIX: 0.0487

FCONS_SCORE: 1.2415

RIG_SCORE: 0.7558

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M232L	TCGA-22-4594	LUSC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2778
p.A234D	TCGA-68-7755	LUSC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.A233S	TCGA-98-7454	LUSC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.25
p.S224L	TCGA-AA-3984	COAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.3056
p.I236T	TCGA-B5-A3FC	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.1667
p.T230I	TCGA-BR-8077	STAD	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.7078
p.A233T	TCGA-BS-A0UV	UCEC	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.25
p.R240K	TCGA-FR-A728	SKCM	TCGA	DSGNYT	DEG_SCF_TRCP1_1	0.0556
p.S239L	DO3644	BRCA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1944
p.S239L	DO41379	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1944
p.S239T	DO4122	BRCA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1944
p.S219L	DO9002	COAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1667
p.A229D	DO26512	LUSC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.7793
p.A228S	DO26460	LUSC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.M227L	DO27476	LUSC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.711
p.K234R	DO220895	MELA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.R217W	DO28763	OV	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1111
p.A240D	DO30490	OV	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.0556
p.G222E	DO218892	SKCA	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.25
p.R235K	DO48550	SKCM	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.1944
p.T225I	DO38189	STAD	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.7078
p.I231T	DO41871	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.3056
p.A228T	DO42793	UCEC	ICGC	DSGNYT	DEG_SCF_TRCP1_1	0.7139
p.S226A	SIDM00594	Acute Myeloid Leukemia	GDSC	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.S226A	ACH-000004	Leukemia	CCLE	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.S226A	ACH-000005	Leukemia	CCLE	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.S226A	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.S226A	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.7588
p.V237M	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	DSGNYT	DEG_SCF_TRCP1_1	0.1389
p.V237M	ACH-000021	Lung Cancer	CCLE	DSGNYT	DEG_SCF_TRCP1_1	0.1389
p.V237M	NCI-H1693	lung	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.1389
p.S221A	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.S221A	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.2222
p.E227G	IST-MEL1	skin	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.7199
p.V232M	NCI-H1693	lung	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.2778
p.L238Q	HT55	large_intestine	COSMIC	DSGNYT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXZ4	Netrin receptor UNC5D	DEG_SCF_TRCP1_1	225:230	DSGNYT	BTRC	0.9083	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_TRCP1_1	2412:2417	DSGNYT	BTRC	0.7685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGNYT

Degron related mutations and impact score

Drug responses associated with UNC5D mutations

All proteins holding degron of DSGNYT