DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SPOP_SBC_1

Location: 1455:1459

E3 ligase: SPOP

DEGRON score: 0.7738

ASA_SCORE: 74.36

COIL: 0.4556

CONS_SCORE: 0.3209

DSS_SCORE: 0.4973

HELIX: 0.075

FCONS_SCORE: 1.1355

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1461H	TCGA-55-7907	LUAD	TCGA	AETTT	DEG_SPOP_SBC_1	0.2778
p.D1461H	DO25396	LUAD	ICGC	AETTT	DEG_SPOP_SBC_1	0.2778
p.L1460I	TCGA-62-A46R	LUAD	TCGA	AETTT	DEG_SPOP_SBC_1	0.3056
p.L1460I	TCGA-BQ-7059	KIRP	TCGA	AETTT	DEG_SPOP_SBC_1	0.3056
p.L1460I	DO20932	KIRP	ICGC	AETTT	DEG_SPOP_SBC_1	0.3056
p.L1460I	DO45355	LUAD	ICGC	AETTT	DEG_SPOP_SBC_1	0.3056
p.T1459I	TCGA-DK-A1A3	BLCA	TCGA	AETTT	DEG_SPOP_SBC_1	0.7078
p.T1459I	DO558	BLCA	ICGC	AETTT	DEG_SPOP_SBC_1	0.7078
p.T1459I	SIDM01658	Unknown	GDSC	AETTT	DEG_SPOP_SBC_1	0.7078
p.T1459I	SIDM01413	Oral Cavity Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.7078
p.T1459I	ACH-000598	Myeloma	CCLE	AETTT	DEG_SPOP_SBC_1	0.7078
p.T1459I	ACH-000630	Head and Neck Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.7078
p.E1456K	DO220866	MELA	ICGC	AETTT	DEG_SPOP_SBC_1	0.591
p.E1466Q	DO27879	ORCA	ICGC	AETTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1849:1853	AETTT	SPOP	0.6364	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7429:7433	AETTT	SPOP	0.7185	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7719:7723	AETTT	SPOP	0.9434	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	335:339	AETTT	SPOP	0.9978	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1455:1459	AETTT	SPOP	0.7738	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	823:827	AETTT	SPOP	0.55	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	268:272	AETTT	SPOP	0.6592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons