DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AETTT
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SPOP_SBC_1
Location:
268:272
E3 ligase:
SPOP
DEGRON score:
0.6592
ASA_SCORE:
93.48
COIL:
0.9276
CONS_SCORE:
0.107
DSS_SCORE:
0.7374
HELIX:
0.033
FCONS_SCORE:
0.2852
RIG_SCORE:
0.6908
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AETTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13129
Zinc finger protein Rlf
DEG_SPOP_SBC_1
1849:1853
AETTT
SPOP
0.6364
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7429:7433
AETTT
SPOP
0.7185
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7719:7723
AETTT
SPOP
0.9434
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
335:339
AETTT
SPOP
0.9978
More...
Q9NR99
Matrix-remodeling-associated protein 5
DEG_SPOP_SBC_1
1455:1459
AETTT
SPOP
0.7738
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
823:827
AETTT
SPOP
0.55
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
268:272
AETTT
SPOP
0.6592
More...