DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.9978

ASA_SCORE: 97.58

COIL: 0.937

CONS_SCORE: 0.3857

DSS_SCORE: 0.7037

HELIX: 0.022

FCONS_SCORE: 1.1161

RIG_SCORE: 0.6333

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G341S	TCGA-AX-A06F	UCEC	TCGA	AETTT	DEG_SPOP_SBC_1	0.2778
p.G341S	DO41752	UCEC	ICGC	AETTT	DEG_SPOP_SBC_1	0.2778
p.E349G	TCGA-B0-4823	KIRC	TCGA	AETTT	DEG_SPOP_SBC_1	0.0556
p.E349G	DO18492	KIRC	ICGC	AETTT	DEG_SPOP_SBC_1	0.0556
p.E349K	TCGA-EE-A29D	SKCM	TCGA	AETTT	DEG_SPOP_SBC_1	0.0556
p.E349K	DO38123	SKCM	ICGC	AETTT	DEG_SPOP_SBC_1	0.0556
p.L344V	TCGA-Z6-AAPN	ESCA	TCGA	AETTT	DEG_SPOP_SBC_1	0.1944
p.A343V	DO228123	EOPC	ICGC	AETTT	DEG_SPOP_SBC_1	0.2222
p.A329T	DO228496	MALY	ICGC	AETTT	DEG_SPOP_SBC_1	0.1667
p.E336K	SIDM00215	Colorectal Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00586	Hepatocellular Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00473	Oral Cavity Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00463	T-Lymphoblastic Leukemia	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00908	Non-Cancerous	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00619	Thyroid Gland Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00522	Small Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM01217	Other Blood Cancers	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM01617	Endometrial Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM01577	Plasma Cell Myeloma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM01574	Plasma Cell Myeloma	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.E336K	SIDM01756	Chronic Myelogenous Leukemia	GDSC	AETTT	DEG_SPOP_SBC_1	0.591
p.A343T	SIDM01106	Melanoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.2222
p.A343T	ACH-000822	Skin Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.2222
p.A343T	SK-MEL-24	skin	COSMIC	AETTT	DEG_SPOP_SBC_1	0.2222
p.T339N	SIDM00963	Breast Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.7055
p.T339N	ACH-000927	Breast Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.7055
p.T339N	BT-474	breast	COSMIC	AETTT	DEG_SPOP_SBC_1	0.7055
p.K349E	SK-GT-2	stomach	COSMIC	AETTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1849:1853	AETTT	SPOP	0.6364	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7429:7433	AETTT	SPOP	0.7185	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7719:7723	AETTT	SPOP	0.9434	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	335:339	AETTT	SPOP	0.9978	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1455:1459	AETTT	SPOP	0.7738	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	823:827	AETTT	SPOP	0.55	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	268:272	AETTT	SPOP	0.6592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of AETTT