DegronMD - Q13129(RLF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V65L	TCGA-44-7660	LUAD	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.V65L	DO23834	LUAD	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.H1837N	TCGA-AG-A002	READ	TCGA	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1944
p.S1832G	TCGA-BG-A0LX	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.6993
p.S1832G	DO41919	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.6993
p.E1838D	TCGA-CV-7440	HNSC	TCGA	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1667
p.E1838D	DO15078	HNSC	ICGC	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1667
p.V65M	TCGA-D1-A103	UCEC	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.V65M	DO11854	GBM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.V65M	DO42312	UCEC	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1111
p.P1828H	TCGA-D9-A148	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7694
p.P1828H	DO37971	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation altering degron motif	0.7694
p.S47L	TCGA-EB-A44N	SKCM	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.7222
p.S47L	DO47638	SKCM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation blocking phosphorylation signal	0.7222
p.P39S	TCGA-EB-A5FP	SKCM	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556
p.P39S	DO47362	SKCM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556
p.P1823S	DO227549	COCA	ICGC	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.1944
p.E62D	DO229028	LICA	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1944
p.V1825F	DO229027	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	1828:1832	Mutation rewiring degron network	0.25
p.P1845S	SIDM01314	Colorectal Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.2222
p.R1861G	SIDM00373	Endometrial Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1111
p.R1861G	ACH-000974	Endometrial/Uterine Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1111
p.T1853A	SIDM00524	Small Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation altering degron motif	0.7139
p.P1844S	SIDM00290	Gastric Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1944
p.P1844S	ACH-000847	Gastric Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1944
p.P1844S	HGC-27	stomach	COSMIC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1944
p.P42S	SIDM00968	Ovarian Carcinoma	GDSC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.P42S	ACH-002140	Ovarian Cancer	CCLE	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.P42S	Hey	ovary	COSMIC	LRPCLWQLE	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.L1860M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1389
p.L1860M	ACH-000637	Esophageal Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1389
p.L1860M	KYSE-520	oesophagus	COSMIC	AETTT	DEG_SPOP_SBC_1	1849:1853	Mutation rewiring degron network	0.1389

Kaplan plot for RLF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RLF

UniProt ID: Q13129

Entrez ID: 6018

Protein name: Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RLF in