DegronMD

Uniprot ID: Q13129

Source protein: Zinc finger protein Rlf

Source gene: RLF

Class: DEG_APCC_DBOX_1

Location: 49:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9086

ASA_SCORE: 54.9556

COIL: 0.0463

CONS_SCORE: 0.6478

DSS_SCORE: 0.3371

HELIX: 0.9478

FCONS_SCORE: 1.1829

RIG_SCORE: 0.8251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V65L	TCGA-44-7660	LUAD	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	0.1111
p.V65L	DO23834	LUAD	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1111
p.V65M	TCGA-D1-A103	UCEC	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	0.1111
p.V65M	DO11854	GBM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1111
p.V65M	DO42312	UCEC	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1111
p.S47L	TCGA-EB-A44N	SKCM	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	0.7222
p.S47L	DO47638	SKCM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.7222
p.P39S	TCGA-EB-A5FP	SKCM	TCGA	LRPCLWQLE	DEG_APCC_DBOX_1	0.0556
p.P39S	DO47362	SKCM	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.0556
p.E62D	DO229028	LICA	ICGC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1944
p.P42S	SIDM00968	Ovarian Carcinoma	GDSC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1389
p.P42S	ACH-002140	Ovarian Cancer	CCLE	LRPCLWQLE	DEG_APCC_DBOX_1	0.1389
p.P42S	Hey	ovary	COSMIC	LRPCLWQLE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13129	Zinc finger protein Rlf	DEG_APCC_DBOX_1	49:57	LRPCLWQLE	APC,CDC20,FZR1	0.9086	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons