DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AETTT
Uniprot ID:
Q13129
Source protein:
Zinc finger protein Rlf
Source gene:
RLF
Class:
DEG_SPOP_SBC_1
Location:
1849:1853
E3 ligase:
SPOP
DEGRON score:
0.6364
ASA_SCORE:
78.94
COIL:
0.8048
CONS_SCORE:
0.598
DSS_SCORE:
0.2361
HELIX:
0.1528
FCONS_SCORE:
0.8105
RIG_SCORE:
0.8285
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1853A
SIDM00524
Small Cell Lung Carcinoma
GDSC
AETTT
DEG_SPOP_SBC_1
0.7139
p.P1845S
SIDM01314
Colorectal Carcinoma
GDSC
AETTT
DEG_SPOP_SBC_1
0.2222
p.P1844S
SIDM00290
Gastric Carcinoma
GDSC
AETTT
DEG_SPOP_SBC_1
0.1944
p.P1844S
ACH-000847
Gastric Cancer
CCLE
AETTT
DEG_SPOP_SBC_1
0.1944
p.P1844S
HGC-27
stomach
COSMIC
AETTT
DEG_SPOP_SBC_1
0.1944
p.L1860M
SIDM01025
Esophageal Squamous Cell Carcinoma
GDSC
AETTT
DEG_SPOP_SBC_1
0.1389
p.L1860M
ACH-000637
Esophageal Cancer
CCLE
AETTT
DEG_SPOP_SBC_1
0.1389
p.L1860M
KYSE-520
oesophagus
COSMIC
AETTT
DEG_SPOP_SBC_1
0.1389
p.R1861G
SIDM00373
Endometrial Carcinoma
GDSC
AETTT
DEG_SPOP_SBC_1
0.1111
p.R1861G
ACH-000974
Endometrial/Uterine Cancer
CCLE
AETTT
DEG_SPOP_SBC_1
0.1111
Showing 1 to 10 of 10 entries
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Drug responses associated with RLF mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of AETTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NR99
Matrix-remodeling-associated protein 5
DEG_SPOP_SBC_1
1455:1459
AETTT
SPOP
0.7738
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7429:7433
AETTT
SPOP
0.7185
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7719:7723
AETTT
SPOP
0.9434
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
823:827
AETTT
SPOP
0.55
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
335:339
AETTT
SPOP
0.9978
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
268:272
AETTT
SPOP
0.6592
More...
Q13129
Zinc finger protein Rlf
DEG_SPOP_SBC_1
1849:1853
AETTT
SPOP
0.6364
More...
Showing 1 to 7 of 7 entries
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