DegronMD

Uniprot ID: Q13129

Source protein: Zinc finger protein Rlf

Source gene: RLF

Class: DEG_SPOP_SBC_1

Location: 1849:1853

E3 ligase: SPOP

DEGRON score: 0.6364

ASA_SCORE: 78.94

COIL: 0.8048

CONS_SCORE: 0.598

DSS_SCORE: 0.2361

HELIX: 0.1528

FCONS_SCORE: 0.8105

RIG_SCORE: 0.8285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1845S	SIDM01314	Colorectal Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.2222
p.R1861G	SIDM00373	Endometrial Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.1111
p.R1861G	ACH-000974	Endometrial/Uterine Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.1111
p.T1853A	SIDM00524	Small Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.7139
p.P1844S	SIDM00290	Gastric Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.1944
p.P1844S	ACH-000847	Gastric Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.1944
p.P1844S	HGC-27	stomach	COSMIC	AETTT	DEG_SPOP_SBC_1	0.1944
p.L1860M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	0.1389
p.L1860M	ACH-000637	Esophageal Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	0.1389
p.L1860M	KYSE-520	oesophagus	COSMIC	AETTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1849:1853	AETTT	SPOP	0.6364	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7429:7433	AETTT	SPOP	0.7185	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7719:7723	AETTT	SPOP	0.9434	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	335:339	AETTT	SPOP	0.9978	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1455:1459	AETTT	SPOP	0.7738	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	823:827	AETTT	SPOP	0.55	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	268:272	AETTT	SPOP	0.6592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons