DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SCF_FBW7_1

Location: 1001:1006

E3 ligase: FBXW7

DEGRON score: 0.8541

ASA_SCORE: 65.05

COIL: 0.683

CONS_SCORE: 0.2911

DSS_SCORE: 0.5198

HELIX: 0.0175

FCONS_SCORE: 1.0692

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K992E	TCGA-56-8305	LUSC	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.1944
p.K992E	DO223725	LUSC	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.1944
p.V1009G	TCGA-AA-3684	COAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.25
p.V1009G	DO8802	COAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.25
p.P1005S	TCGA-D3-A2J8	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.5641
p.P1005S	TCGA-EE-A2M5	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.5641
p.P1005S	DO222423	MELA	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.5641
p.P1005S	DO37778	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.5641
p.P1005S	DO37425	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.5641
p.P1003Q	TCGA-DA-A1I4	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.7035
p.P1003Q	DO37655	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.7035
p.L1001P	TCGA-EE-A29E	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.6471
p.L1001P	DO37831	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.6471
p.M993I	TCGA-W3-A825	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.1111
p.M993I	DO51272	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.1111
p.P1005T	TCGA-ZG-A9NI	PRAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.5919
p.P1005T	DO219448	PRAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.5919
p.I1007V	ACH-001030	Bone Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.3056
p.V1009L	ACH-001649	Prostate Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20908	Collagen alpha-1	DEG_SCF_FBW7_1	310:315	LTPTPT	FBXW7	0.997	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_FBW7_1	1001:1006	LTPTPT	FBXW7	0.8541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons