DegronMD

Uniprot ID: P20908

Source protein: Collagen alpha-1

Source gene: COL5A1

Class: DEG_SCF_FBW7_1

Location: 310:315

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 72.0333

COIL: 0.9095

CONS_SCORE: 0.2733

DSS_SCORE: 0.8364

HELIX: 0.0405

FCONS_SCORE: 1.1465

RIG_SCORE: 0.6649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M320V	TCGA-AO-A128	BRCA	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.1944
p.M320V	DO5326	BRCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.1944
p.T311S	TCGA-AR-A2LO	BRCA	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.7116
p.T311S	DO2383	BRCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.7116
p.T315P	TCGA-AX-A05Z	UCEC	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.7031
p.T315P	DO40884	UCEC	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.7031
p.A317T	TCGA-BF-A5EQ	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.A317T	DO219452	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.T313S	TCGA-D1-A15X	UCEC	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.6005
p.T313S	DO43274	UCEC	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.6005
p.A317S	TCGA-MN-A4N4	LUAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.A317S	DO26250	LUAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.P314H	TCGA-V1-A9Z8	PRAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.6583
p.P314H	DO219393	PRAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.6583
p.E308K	TCGA-VQ-A91K	STAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.E308K	DO51785	STAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.2778
p.T315M	DO48425	BLCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	0.7423
p.P307L	SIDM00660	Colorectal Carcinoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	0.25
p.P307L	ACH-000985	Colon/Colorectal Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.25
p.P307L	LS-411N	large_intestine	COSMIC	LTPTPT	DEG_SCF_FBW7_1	0.25
p.A300S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	0.0556
p.A300S	ACH-000488	Esophageal Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.0556
p.A300S	TE-11	oesophagus	COSMIC	LTPTPT	DEG_SCF_FBW7_1	0.0556
p.A318D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	0.25
p.A318D	ACH-001498	Lymphoma	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.25
p.A318D	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LTPTPT	DEG_SCF_FBW7_1	0.25
p.A300T	ACH-001664	Gastric Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20908	Collagen alpha-1	DEG_SCF_FBW7_1	310:315	LTPTPT	FBXW7	0.997	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_FBW7_1	1001:1006	LTPTPT	FBXW7	0.8541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPTPT

Degron related mutations and impact score

Drug responses associated with COL5A1 mutations

All proteins holding degron of LTPTPT