DegronMD - P20908(COL5A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E284K	TCGA-2W-A8YY	CESC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	TCGA-AP-A056	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	TCGA-B5-A3FA	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	DO223732	CESC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	DO234418	ESAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	DO52402	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	DO43971	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.E284K	SIDM01449	Pancreatic Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.R1709H	TCGA-51-4080	LUSC	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0833
p.R1709H	TCGA-FB-AAPP	PAAD	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0833
p.R1709H	DO26441	LUSC	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0833
p.R1709H	DO218963	PAAD	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0833
p.S343N	TCGA-A5-A2K3	UCEC	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.2778
p.S343N	DO43899	UCEC	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.2778
p.M320V	TCGA-AO-A128	BRCA	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1944
p.M320V	DO5326	BRCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.1944
p.E1688K	TCGA-AP-A1DK	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1111
p.E1688K	DO42033	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1111
p.T311S	TCGA-AR-A2LO	BRCA	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7116
p.T311S	DO2383	BRCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7116
p.T315P	TCGA-AX-A05Z	UCEC	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.T315P	DO40884	UCEC	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7031
p.D282Y	TCGA-AZ-4315	COAD	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1944
p.D282Y	DO8842	COAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1944
p.A317T	TCGA-BF-A5EQ	SKCM	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.A317T	DO219452	SKCM	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.P278T	TCGA-BS-A0UJ	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.0833
p.P278T	DO42745	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.0833
p.V297M	TCGA-CM-6163	COAD	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.V297M	DO9194	COAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.25
p.T313S	TCGA-D1-A15X	UCEC	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6005
p.T313S	DO43274	UCEC	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6005
p.D345G	TCGA-D1-A16D	UCEC	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation altering degron motif	0.7198
p.D345G	DO42217	UCEC	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation altering degron motif	0.7198
p.G360R	TCGA-D3-A2JF	SKCM	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.0833
p.G360R	DO38153	SKCM	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.0833
p.P1700Q	TCGA-D3-A2JN	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation altering degron motif	0.5924
p.P1700Q	DO47590	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation altering degron motif	0.5924
p.G1689R	TCGA-D3-A3MR	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1389
p.G1689R	DO47256	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1389
p.G336E	TCGA-D3-A51G	SKCM	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.0833
p.G336E	DO47700	SKCM	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.0833
p.D353N	TCGA-D3-A8GM	SKCM	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.2778
p.D353N	DO50288	SKCM	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.2778
p.Y347C	TCGA-EO-A22R	UCEC	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation altering degron motif	0.7087
p.Y347C	DO231569	LINC	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation altering degron motif	0.7087
p.Y347C	DO42713	UCEC	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation altering degron motif	0.7087
p.E1688D	TCGA-FI-A2D5	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1111
p.E1688D	DO41331	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1111
p.G287R	TCGA-IH-A3EA	SKCM	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.6457
p.G287R	DO37667	SKCM	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.6457
p.A317S	TCGA-MN-A4N4	LUAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.A317S	DO26250	LUAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.E359K	TCGA-QS-A5YQ	UCEC	TCGA	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.1111
p.E359K	DO49073	UCEC	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.1111
p.P314H	TCGA-V1-A9Z8	PRAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6583
p.P314H	DO219393	PRAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.6583
p.E308K	TCGA-VQ-A91K	STAD	TCGA	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.E308K	DO51785	STAD	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.2778
p.G287E	TCGA-W3-AA1V	SKCM	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.6087
p.G287E	DO51276	SKCM	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.6087
p.P1696S	TCGA-XK-AAIW	PRAD	TCGA	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation altering degron motif	0.5641
p.P1696S	DO51407	PRAD	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation altering degron motif	0.5641
p.T315M	DO48425	BLCA	ICGC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation altering degron motif	0.7423
p.E1698A	DO8264	COAD	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation altering degron motif	0.7701
p.G336R	DO222864	COCA	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.0833
p.P292T	DO233697	GACA	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7031
p.G1710W	DO228971	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0556
p.K1708N	DO229008	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation substituting flanking lysine	0.2222
p.P292H	DO45153	LIRI	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7694
p.S343R	DO46556	OV	ICGC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.2778
p.S1687F	DO229465	SKCA	ICGC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.0833
p.R1694H	SIDM01301	Esophageal Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.2778
p.D354E	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.25
p.D354E	ACH-000510	Lung Cancer	CCLE	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.25
p.D354E	NCI-H1299	lung	COSMIC	DYYTPSP	CBL_PTK	345:351	Mutation rewiring degron network	0.25
p.E289K	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7022
p.E289K	ACH-000647	Esophageal Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7022
p.E289K	TE-1	oesophagus	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation altering degron motif	0.7022
p.P307L	SIDM00660	Colorectal Carcinoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.P307L	ACH-000985	Colon/Colorectal Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.P307L	LS-411N	large intestine	COSMIC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.A300S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.A300S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.A300S	ACH-000488	Esophageal Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.A300S	ACH-000488	Esophageal Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.A300S	TE-11	oesophagus	COSMIC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.A300S	TE-11	oesophagus	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.E281K	SIDM01088	Endometrial Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.E281K	ACH-000965	Endometrial/Uterine Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.E281K	RL95-2	endometrium	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667
p.G1689V	SIDM00365	Small Cell Lung Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1389
p.G1689V	SBC-1	lung	COSMIC	PKENP	DEG_APCC_KENBOX_2	1696:1700	Mutation rewiring degron network	0.1389
p.A318D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.A318D	ACH-001498	Lymphoma	CCLE	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.A318D	Farage	haematopoietic and lymphoid tissue	COSMIC	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.25
p.A300T	ACH-001664	Gastric Cancer	CCLE	LTPTPT	DEG_SCF_FBW7_1	310:315	Mutation rewiring degron network	0.0556
p.A300T	ACH-001664	Gastric Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	287:294	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL5A1

UniProt ID: P20908

Entrez ID: 1289

Protein name: Collagen alpha-1(V) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL5A1 in