DegronMD

Uniprot ID: P20908

Source protein: Collagen alpha-1

Source gene: COL5A1

Class: CBL_PTK

Location: 345:351

E3 ligase: CBL

DEGRON score: 0.9872

ASA_SCORE: 69.4286

COIL: 0.8666

CONS_SCORE: 0.2268

DSS_SCORE: 0.6668

HELIX: 0.0387

FCONS_SCORE: 0.9692

RIG_SCORE: 0.7305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S343N	TCGA-A5-A2K3	UCEC	TCGA	DYYTPSP	CBL_PTK	0.2778
p.S343N	DO43899	UCEC	ICGC	DYYTPSP	CBL_PTK	0.2778
p.D345G	TCGA-D1-A16D	UCEC	TCGA	DYYTPSP	CBL_PTK	0.7198
p.D345G	DO42217	UCEC	ICGC	DYYTPSP	CBL_PTK	0.7198
p.G360R	TCGA-D3-A2JF	SKCM	TCGA	DYYTPSP	CBL_PTK	0.0833
p.G360R	DO38153	SKCM	ICGC	DYYTPSP	CBL_PTK	0.0833
p.G336E	TCGA-D3-A51G	SKCM	TCGA	DYYTPSP	CBL_PTK	0.0833
p.G336E	DO47700	SKCM	ICGC	DYYTPSP	CBL_PTK	0.0833
p.D353N	TCGA-D3-A8GM	SKCM	TCGA	DYYTPSP	CBL_PTK	0.2778
p.D353N	DO50288	SKCM	ICGC	DYYTPSP	CBL_PTK	0.2778
p.Y347C	TCGA-EO-A22R	UCEC	TCGA	DYYTPSP	CBL_PTK	0.7087
p.Y347C	DO231569	LINC	ICGC	DYYTPSP	CBL_PTK	0.7087
p.Y347C	DO42713	UCEC	ICGC	DYYTPSP	CBL_PTK	0.7087
p.E359K	TCGA-QS-A5YQ	UCEC	TCGA	DYYTPSP	CBL_PTK	0.1111
p.E359K	DO49073	UCEC	ICGC	DYYTPSP	CBL_PTK	0.1111
p.G336R	DO222864	COCA	ICGC	DYYTPSP	CBL_PTK	0.0833
p.S343R	DO46556	OV	ICGC	DYYTPSP	CBL_PTK	0.2778
p.D354E	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DYYTPSP	CBL_PTK	0.25
p.D354E	ACH-000510	Lung Cancer	CCLE	DYYTPSP	CBL_PTK	0.25
p.D354E	NCI-H1299	lung	COSMIC	DYYTPSP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20908	Collagen alpha-1	CBL_PTK	345:351	DYYTPSP	CBL	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons