DegronMD

Uniprot ID: P20908

Source protein: Collagen alpha-1

Source gene: COL5A1

Class: DEG_APCC_KENBOX_2

Location: 1696:1700

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 86.66

COIL: 0.9158

CONS_SCORE: 0.3493

DSS_SCORE: 0.3768

HELIX: 0.0452

FCONS_SCORE: 1.0056

RIG_SCORE: 0.726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1709H	TCGA-51-4080	LUSC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.0833
p.R1709H	TCGA-FB-AAPP	PAAD	TCGA	PKENP	DEG_APCC_KENBOX_2	0.0833
p.R1709H	DO26441	LUSC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0833
p.R1709H	DO218963	PAAD	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0833
p.E1688K	TCGA-AP-A1DK	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1111
p.E1688K	DO42033	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1111
p.P1700Q	TCGA-D3-A2JN	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	0.5924
p.P1700Q	DO47590	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	0.5924
p.G1689R	TCGA-D3-A3MR	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1389
p.G1689R	DO47256	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.E1688D	TCGA-FI-A2D5	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1111
p.E1688D	DO41331	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1111
p.P1696S	TCGA-XK-AAIW	PRAD	TCGA	PKENP	DEG_APCC_KENBOX_2	0.5641
p.P1696S	DO51407	PRAD	ICGC	PKENP	DEG_APCC_KENBOX_2	0.5641
p.E1698A	DO8264	COAD	ICGC	PKENP	DEG_APCC_KENBOX_2	0.7701
p.G1710W	DO228971	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0556
p.K1708N	DO229008	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.2222
p.S1687F	DO229465	SKCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0833
p.R1694H	SIDM01301	Esophageal Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	0.2778
p.G1689V	SIDM00365	Small Cell Lung Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.G1689V	SBC-1	lung	COSMIC	PKENP	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_APCC_KENBOX_2	527:531	PKENP	APC,CDC20,FZR1	0.8774	More...
P20908	Collagen alpha-1	DEG_APCC_KENBOX_2	1696:1700	PKENP	APC,CDC20,FZR1	0.9351	More...
P78524	DENN domain-containing protein 2B	DEG_APCC_KENBOX_2	496:500	PKENP	APC,CDC20,FZR1	0.9888	More...
Q8TAT2	Fibroblast growth factor-binding protein 3	DEG_APCC_KENBOX_2	195:199	PKENP	APC,CDC20,FZR1	0.9762	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	629:633	PKENP	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons