DegronMD

Uniprot ID: Q8TAT2

Source protein: Fibroblast growth factor-binding protein 3

Source gene: FGFBP3

Class: DEG_APCC_KENBOX_2

Location: 195:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9762

ASA_SCORE: 115.42

COIL: 0.9516

CONS_SCORE: 0.3511

DSS_SCORE: 0.9022

HELIX: 0.0304

FCONS_SCORE: 1.0596

RIG_SCORE: 0.5022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A185D	TCGA-B5-A11E	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.0556
p.A185D	DO41644	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0556
p.P195S	DO222769	COCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.5641
p.S200A	DO228533	GACA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.75
p.P199L	DO231057	LUSC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_APCC_KENBOX_2	527:531	PKENP	APC,CDC20,FZR1	0.8774	More...
P20908	Collagen alpha-1	DEG_APCC_KENBOX_2	1696:1700	PKENP	APC,CDC20,FZR1	0.9351	More...
P78524	DENN domain-containing protein 2B	DEG_APCC_KENBOX_2	496:500	PKENP	APC,CDC20,FZR1	0.9888	More...
Q8TAT2	Fibroblast growth factor-binding protein 3	DEG_APCC_KENBOX_2	195:199	PKENP	APC,CDC20,FZR1	0.9762	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	629:633	PKENP	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons