DegronMD - Q70EK8(USP53)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D398H	TCGA-13-1498	OV	TCGA	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.25
p.D398H	DO30180	OV	ICGC	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.25
p.E788K	TCGA-AR-A2LE	BRCA	TCGA	RSHVHED	LIG_APCC_ABBAyCdc20_2	783:789	Mutation altering degron motif	0.591
p.E788K	TCGA-N8-A4PI	UCS	TCGA	RSHVHED	LIG_APCC_ABBAyCdc20_2	783:789	Mutation altering degron motif	0.591
p.E788K	DO1932	BRCA	ICGC	RSHVHED	LIG_APCC_ABBAyCdc20_2	783:789	Mutation altering degron motif	0.591
p.G395R	TCGA-BR-4362	STAD	TCGA	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation altering degron motif	0.6457
p.G395R	DO38336	STAD	ICGC	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation altering degron motif	0.6457
p.M639I	TCGA-C5-A1M7	CESC	TCGA	PKENP	DEG_APCC_KENBOX_2	629:633	Mutation rewiring degron network	0.1667
p.M639I	DO48981	CESC	ICGC	PKENP	DEG_APCC_KENBOX_2	629:633	Mutation rewiring degron network	0.1667
p.M639I	DO229038	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	629:633	Mutation rewiring degron network	0.1667
p.G1012V	TCGA-J9-A8CM	PRAD	TCGA	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012V	DO219267	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.V384I	TCGA-UZ-A9PS	KIRP	TCGA	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1389
p.V384I	DO219709	KIRP	ICGC	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1389
p.S1000F	TCGA-YD-A89C	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation altering degron motif	0.6871
p.S1000F	DO219501	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation altering degron motif	0.6871
p.A1009S	DO228952	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.1667
p.Q399H	DO229027	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.2222
p.A400S	DO229037	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	391:395	Mutation rewiring degron network	0.1944
p.H779Y	DO222632	MELA	ICGC	RSHVHED	LIG_APCC_ABBAyCdc20_2	783:789	Mutation rewiring degron network	0.2222
p.P633S	DO229459	SKCA	ICGC	PKENP	DEG_APCC_KENBOX_2	629:633	Mutation altering degron motif	0.5641
p.Q635K	DO229234	THCA	ICGC	PKENP	DEG_APCC_KENBOX_2	629:633	Mutation rewiring degron network	0.2778
p.G1012D	SIDM00611	Kidney Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	SIDM00352	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	SIDM00243	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	SIDM01460	Glioma	GDSC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	ACH-000592	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	ACH-000684	Kidney Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	ACH-000719	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	ACH-002288	Embryonal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	KMRC-1	kidney	COSMIC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	NEC8	testis	COSMIC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.G1012D	RMG-I	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.0833
p.F1007V	SIDM01611	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.2222
p.F1007V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	999:1003	Mutation rewiring degron network	0.2222
p.G791A	ACH-000829	Myeloma	CCLE	RSHVHED	LIG_APCC_ABBAyCdc20_2	783:789	Mutation rewiring degron network	0.2778

Kaplan plot for USP53 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP53

UniProt ID: Q70EK8

Entrez ID: 54532

Protein name: Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin-specific peptidase 53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP53 in