DegronMD

Uniprot ID: Q70EK8

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 53

Source gene: USP53

Class: LIG_APCC_ABBAyCdc20_2

Location: 783:789

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7493

ASA_SCORE: 101.6429

COIL: 0.6963

CONS_SCORE: 0.4249

DSS_SCORE: 0.5028

HELIX: 0.2297

FCONS_SCORE: 0.9879

RIG_SCORE: 0.6941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E788K	TCGA-AR-A2LE	BRCA	TCGA	RSHVHED	LIG_APCC_ABBAyCdc20_2	0.591
p.E788K	TCGA-N8-A4PI	UCS	TCGA	RSHVHED	LIG_APCC_ABBAyCdc20_2	0.591
p.E788K	DO1932	BRCA	ICGC	RSHVHED	LIG_APCC_ABBAyCdc20_2	0.591
p.H779Y	DO222632	MELA	ICGC	RSHVHED	LIG_APCC_ABBAyCdc20_2	0.2222
p.G791A	ACH-000829	Myeloma	CCLE	RSHVHED	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	LIG_APCC_ABBAyCdc20_2	783:789	RSHVHED	APC,CDC20,FZR1	0.7493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons