DegronMD

Uniprot ID: Q70EK8

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 53

Source gene: USP53

Class: DEG_APCC_KENBOX_2

Location: 391:395

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8999

ASA_SCORE: 95.68

COIL: 0.7998

CONS_SCORE: 0.4127

DSS_SCORE: 0.5967

HELIX: 0.1744

FCONS_SCORE: 1.043

RIG_SCORE: 0.6758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D398H	TCGA-13-1498	OV	TCGA	LKENG	DEG_APCC_KENBOX_2	0.25
p.D398H	DO30180	OV	ICGC	LKENG	DEG_APCC_KENBOX_2	0.25
p.G395R	TCGA-BR-4362	STAD	TCGA	LKENG	DEG_APCC_KENBOX_2	0.6457
p.G395R	DO38336	STAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.6457
p.V384I	TCGA-UZ-A9PS	KIRP	TCGA	LKENG	DEG_APCC_KENBOX_2	0.1389
p.V384I	DO219709	KIRP	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1389
p.Q399H	DO229027	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.2222
p.A400S	DO229037	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	DEG_APCC_KENBOX_2	702:706	LKENG	APC,CDC20,FZR1	0.5766	More...
Q6PKG0	La-related protein 1	DEG_APCC_KENBOX_2	880:884	LKENG	APC,CDC20,FZR1	0.835	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_APCC_KENBOX_2	939:943	LKENG	APC,CDC20,FZR1	0.7159	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	33685:33689	LKENG	APC,CDC20,FZR1	0.5202	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	391:395	LKENG	APC,CDC20,FZR1	0.8999	More...
Q8IX06	Putative exonuclease GOR	DEG_APCC_KENBOX_2	380:384	LKENG	APC,CDC20,FZR1	0.667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons