DegronMD - Q8N1G1(REXO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R930M	TCGA-BQ-7053	KIRP	TCGA	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0833
p.R930M	DO20946	KIRP	ICGC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0833
p.G953R	TCGA-EE-A2GB	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0556
p.G953R	DO222683	MELA	ICGC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0556
p.G953R	DO37417	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0556
p.G953R	SIDM01612	Endometrial Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0556
p.G953R	ACH-000946	Endometrial/Uterine Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.0556
p.V626I	TCGA-EK-A2RO	CESC	TCGA	LRIFNE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2222
p.V626I	DO49960	CESC	ICGC	LRIFNE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2222
p.V626I	ACH-000088	Non-Cancerous	CCLE	LRIFNE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2222
p.E941D	TCGA-EY-A1GI	UCEC	TCGA	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation altering degron motif	0.6758
p.E941D	DO41211	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation altering degron motif	0.6758
p.T624S	TCGA-XE-AAO4	TGCT	TCGA	LRIFNE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2778
p.P580T	DO229010	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.5919
p.S577P	DO228933	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.S577P	DO219881	SKCA	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.S577P	DO229515	SKCA	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2778
p.H948L	DO222837	MELA	ICGC	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation rewiring degron network	0.1944
p.S585F	DO37719	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation blocking phosphorylation signal	0.7222
p.P574L	DO38376	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1944
p.S592N	DO229250	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.P612L	SIDM01133	Other Solid Cancers	GDSC	LRIFNE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1944
p.N942S	ACH-000760	Brain Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	939:943	Mutation altering degron motif	0.7069
p.S585C	ACH-000871	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	579:583	Mutation blocking phosphorylation signal	0.7222
p.A593S	ACH-001740	Sarcoma	CCLE	APSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556

Kaplan plot for REXO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REXO1

UniProt ID: Q8N1G1

Entrez ID: 57455

Protein name: RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REXO1 in