DegronMD

Uniprot ID: Q8N1G1

Source protein: RNA exonuclease 1 homolog

Source gene: REXO1

Class: LIG_APCC_ABBA_1

Location: 617:622

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.821

ASA_SCORE: 76.3833

COIL: 0.2107

CONS_SCORE: 0.3501

DSS_SCORE: 0.5052

HELIX: 0.7755

FCONS_SCORE: 1.1566

RIG_SCORE: 0.7893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V626I	TCGA-EK-A2RO	CESC	TCGA	LRIFNE	LIG_APCC_ABBA_1	0.2222
p.V626I	DO49960	CESC	ICGC	LRIFNE	LIG_APCC_ABBA_1	0.2222
p.V626I	ACH-000088	Non-Cancerous	CCLE	LRIFNE	LIG_APCC_ABBA_1	0.2222
p.T624S	TCGA-XE-AAO4	TGCT	TCGA	LRIFNE	LIG_APCC_ABBA_1	0.2778
p.P612L	SIDM01133	Other Solid Cancers	GDSC	LRIFNE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1G1	RNA exonuclease 1 homolog	LIG_APCC_ABBA_1	617:622	LRIFNE	APC,CDC20,FZR1	0.821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons