DegronMD

Uniprot ID: Q8N1G1

Source protein: RNA exonuclease 1 homolog

Source gene: REXO1

Class: DEG_APCC_KENBOX_2

Location: 939:943

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7159

ASA_SCORE: 63.1

COIL: 0.3726

CONS_SCORE: 0.4706

DSS_SCORE: 0.4995

HELIX: 0.6248

FCONS_SCORE: 1.3002

RIG_SCORE: 0.6814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R930M	TCGA-BQ-7053	KIRP	TCGA	LKENG	DEG_APCC_KENBOX_2	0.0833
p.R930M	DO20946	KIRP	ICGC	LKENG	DEG_APCC_KENBOX_2	0.0833
p.G953R	TCGA-EE-A2GB	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.0556
p.G953R	DO222683	MELA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.G953R	DO37417	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.G953R	SIDM01612	Endometrial Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.G953R	ACH-000946	Endometrial/Uterine Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	0.0556
p.E941D	TCGA-EY-A1GI	UCEC	TCGA	LKENG	DEG_APCC_KENBOX_2	0.6758
p.E941D	DO41211	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.6758
p.H948L	DO222837	MELA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944
p.N942S	ACH-000760	Brain Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	DEG_APCC_KENBOX_2	702:706	LKENG	APC,CDC20,FZR1	0.5766	More...
Q6PKG0	La-related protein 1	DEG_APCC_KENBOX_2	880:884	LKENG	APC,CDC20,FZR1	0.835	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_APCC_KENBOX_2	939:943	LKENG	APC,CDC20,FZR1	0.7159	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	33685:33689	LKENG	APC,CDC20,FZR1	0.5202	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	391:395	LKENG	APC,CDC20,FZR1	0.8999	More...
Q8IX06	Putative exonuclease GOR	DEG_APCC_KENBOX_2	380:384	LKENG	APC,CDC20,FZR1	0.667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons