DegronMD

Uniprot ID: Q6PKG0

Source protein: La-related protein 1

Source gene: LARP1

Class: DEG_APCC_KENBOX_2

Location: 880:884

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.835

ASA_SCORE: 81.84

COIL: 0.6538

CONS_SCORE: 0.5185

DSS_SCORE: 0.4262

HELIX: 0.3484

FCONS_SCORE: 1.0082

RIG_SCORE: 0.7009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R879Q	TCGA-AY-5543	COAD	TCGA	LKENG	DEG_APCC_KENBOX_2	0.3056
p.R879Q	DO9748	COAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.3056
p.R879Q	SIDM00534	Colorectal Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	0.3056
p.R879Q	ACH-000986	Colon/Colorectal Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	0.3056
p.R879Q	HT-115	large_intestine	COSMIC	LKENG	DEG_APCC_KENBOX_2	0.3056
p.F894L	TCGA-Q1-A73O	CESC	TCGA	LKENG	DEG_APCC_KENBOX_2	0.0556
p.F894L	DO51612	CESC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.K887N	DO48442	BLCA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.25
p.Y880N	DO234462	ESAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.7059
p.G884V	DO228948	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.6421
p.G884V	DO229028	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.6421
p.Y881C	DO228974	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.7087
p.Y870F	SIDM01176	B-Lymphoblastic Leukemia	GDSC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.Y870F	ACH-000059	Leukemia	CCLE	LKENG	DEG_APCC_KENBOX_2	0.0556
p.Y870F	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	LKENG	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	DEG_APCC_KENBOX_2	702:706	LKENG	APC,CDC20,FZR1	0.5766	More...
Q6PKG0	La-related protein 1	DEG_APCC_KENBOX_2	880:884	LKENG	APC,CDC20,FZR1	0.835	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_APCC_KENBOX_2	939:943	LKENG	APC,CDC20,FZR1	0.7159	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	33685:33689	LKENG	APC,CDC20,FZR1	0.5202	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	391:395	LKENG	APC,CDC20,FZR1	0.8999	More...
Q8IX06	Putative exonuclease GOR	DEG_APCC_KENBOX_2	380:384	LKENG	APC,CDC20,FZR1	0.667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons