DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LKENG
Uniprot ID:
Q8IX06
Source protein:
Putative exonuclease GOR
Source gene:
REXO1L1P
Class:
DEG_APCC_KENBOX_2
Location:
380:384
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.667
ASA_SCORE:
68.6
COIL:
0.3664
CONS_SCORE:
0.4055
DSS_SCORE:
0.5196
HELIX:
0.6312
FCONS_SCORE:
1.3518
RIG_SCORE:
0.6919
Degron related mutations and impact score
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Degron
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Drug responses associated with REXO1L1P mutations
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All proteins holding degron of LKENG
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q70EK8
Inactive ubiquitin carboxyl-terminal hydrolase 53
DEG_APCC_KENBOX_2
391:395
LKENG
APC,CDC20,FZR1
0.8999
More...
Q6PKG0
La-related protein 1
DEG_APCC_KENBOX_2
880:884
LKENG
APC,CDC20,FZR1
0.835
More...
Q659C4
La-related protein 1B
DEG_APCC_KENBOX_2
702:706
LKENG
APC,CDC20,FZR1
0.5766
More...
Q8IX06
Putative exonuclease GOR
DEG_APCC_KENBOX_2
380:384
LKENG
APC,CDC20,FZR1
0.667
More...
Q8N1G1
RNA exonuclease 1 homolog
DEG_APCC_KENBOX_2
939:943
LKENG
APC,CDC20,FZR1
0.7159
More...
Q8WZ42
Titin
DEG_APCC_KENBOX_2
33685:33689
LKENG
APC,CDC20,FZR1
0.5202
More...
Showing 1 to 6 of 6 entries
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