DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LKENG
Uniprot ID:
Q8IX06
Source protein:
Putative exonuclease GOR
Source gene:
REXO1L1P
Class:
DEG_APCC_KENBOX_2
Location:
380:384
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.667
ASA_SCORE:
68.6
COIL:
0.3664
CONS_SCORE:
0.4055
DSS_SCORE:
0.5196
HELIX:
0.6312
FCONS_SCORE:
1.3518
RIG_SCORE:
0.6919
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with REXO1L1P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q659C4
La-related protein 1B
DEG_APCC_KENBOX_2
702:706
LKENG
APC,CDC20,FZR1
0.5766
More...
Q6PKG0
La-related protein 1
DEG_APCC_KENBOX_2
880:884
LKENG
APC,CDC20,FZR1
0.835
More...
Q8N1G1
RNA exonuclease 1 homolog
DEG_APCC_KENBOX_2
939:943
LKENG
APC,CDC20,FZR1
0.7159
More...
Q8WZ42
Titin
DEG_APCC_KENBOX_2
33685:33689
LKENG
APC,CDC20,FZR1
0.5202
More...
Q70EK8
Inactive ubiquitin carboxyl-terminal hydrolase 53
DEG_APCC_KENBOX_2
391:395
LKENG
APC,CDC20,FZR1
0.8999
More...
Q8IX06
Putative exonuclease GOR
DEG_APCC_KENBOX_2
380:384
LKENG
APC,CDC20,FZR1
0.667
More...