DegronMD

Uniprot ID: Q659C4

Source protein: La-related protein 1B

Source gene: LARP1B

Class: DEG_APCC_KENBOX_2

Location: 702:706

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5766

ASA_SCORE: 84.62

COIL: 0.6628

CONS_SCORE: 0.5243

DSS_SCORE: 0.4322

HELIX: 0.3418

FCONS_SCORE: 1.0395

RIG_SCORE: 0.7227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q710P	TCGA-A6-6780	COAD	TCGA	LKENG	DEG_APCC_KENBOX_2	0.2222
p.Q710P	DO10244	COAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.2222
p.Q709K	TCGA-CR-7389	HNSC	TCGA	LKENG	DEG_APCC_KENBOX_2	0.25
p.Q709K	DO14190	HNSC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.25
p.P697S	TCGA-EB-A3Y7	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.1944
p.P697S	DO37499	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944
p.P697L	TCGA-EB-A3Y7	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.1944
p.P697L	DO37499	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944
p.H713N	TCGA-EE-A2GN	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.1389
p.H713N	DO37896	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1389
p.E700K	TCGA-EE-A2MI	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.2778
p.E700K	DO37531	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.2778
p.L701H	TCGA-HU-8238	STAD	TCGA	LKENG	DEG_APCC_KENBOX_2	0.3056
p.R716C	TCGA-MA-AA42	CESC	TCGA	LKENG	DEG_APCC_KENBOX_2	0.0556
p.R716C	DO219724	CESC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.R716C	SIDM01469	Pancreatic Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	0.0556
p.R716C	ACH-000085	Pancreatic Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	0.0556
p.L714I	DO229050	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.2222
p.W703C	DO38551	STAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.7
p.R716H	SIDM00203	Ewing's Sarcoma	GDSC	LKENG	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	DEG_APCC_KENBOX_2	702:706	LKENG	APC,CDC20,FZR1	0.5766	More...
Q6PKG0	La-related protein 1	DEG_APCC_KENBOX_2	880:884	LKENG	APC,CDC20,FZR1	0.835	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_APCC_KENBOX_2	939:943	LKENG	APC,CDC20,FZR1	0.7159	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	33685:33689	LKENG	APC,CDC20,FZR1	0.5202	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	391:395	LKENG	APC,CDC20,FZR1	0.8999	More...
Q8IX06	Putative exonuclease GOR	DEG_APCC_KENBOX_2	380:384	LKENG	APC,CDC20,FZR1	0.667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons