DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_KENBOX_2

Location: 33685:33689

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5202

ASA_SCORE: 82.4

COIL: 0.8232

CONS_SCORE: 0.3

DSS_SCORE: 0.2162

HELIX: 0.0388

FCONS_SCORE: 1.0085

RIG_SCORE: 0.7421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G33676E	TCGA-EE-A2MS	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	0.0833
p.Q33692H	DO229336	BTCA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.25
p.H33690Y	DO10550	COAD	ICGC	LKENG	DEG_APCC_KENBOX_2	0.3056
p.G33689R	DO222769	COCA	ICGC	LKENG	DEG_APCC_KENBOX_2	0.6457
p.H33694Y	DO45471	LUSC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944
p.E33687K	DO47268	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	0.7022
p.F33691V	DO41644	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.2778
p.H33694N	DO41211	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	0.1944
p.D33678H	SIDM01156	Small Cell Lung Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	0.1389
p.D33678H	ACH-000890	Lung Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	0.1389
p.D33678H	SW1271	lung	COSMIC	LKENG	DEG_APCC_KENBOX_2	0.1389
p.K33684T	AGS	stomach	COSMIC	LKENG	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	DEG_APCC_KENBOX_2	702:706	LKENG	APC,CDC20,FZR1	0.5766	More...
Q6PKG0	La-related protein 1	DEG_APCC_KENBOX_2	880:884	LKENG	APC,CDC20,FZR1	0.835	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_APCC_KENBOX_2	939:943	LKENG	APC,CDC20,FZR1	0.7159	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	33685:33689	LKENG	APC,CDC20,FZR1	0.5202	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	391:395	LKENG	APC,CDC20,FZR1	0.8999	More...
Q8IX06	Putative exonuclease GOR	DEG_APCC_KENBOX_2	380:384	LKENG	APC,CDC20,FZR1	0.667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons