DegronMD - Q659C4(LARP1B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A73S	TCGA-A5-A0G1	UCEC	TCGA	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.1667
p.Q710P	TCGA-A6-6780	COAD	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.2222
p.Q710P	DO10244	COAD	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.2222
p.G663A	TCGA-C5-A1MH	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	662:666	Mutation altering degron motif	0.6429
p.G663A	DO48982	CESC	ICGC	PGTSS	DEG_SPOP_SBC_1	662:666	Mutation altering degron motif	0.6429
p.S675P	TCGA-CA-6717	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.0833
p.S675P	DO8264	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.0833
p.Q709K	TCGA-CR-7389	HNSC	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.25
p.Q709K	DO14190	HNSC	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.25
p.P697S	TCGA-EB-A3Y7	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.P697S	DO37499	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.P697L	TCGA-EB-A3Y7	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.P697L	DO37499	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.H713N	TCGA-EE-A2GN	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1389
p.H713N	DO37896	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1389
p.E700K	TCGA-EE-A2MI	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.2778
p.E700K	DO37531	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.2778
p.H82Y	TCGA-GM-A2D9	BRCA	TCGA	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6118
p.H82Y	DO4810	BRCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6118
p.L701H	TCGA-HU-8238	STAD	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.3056
p.I898L	TCGA-IQ-A61G	HNSC	TCGA	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.1667
p.R716C	TCGA-MA-AA42	CESC	TCGA	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0556
p.R716C	DO219724	CESC	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0556
p.R716C	SIDM01469	Pancreatic Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0556
p.R716C	ACH-000085	Pancreatic Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0556
p.S890F	TCGA-XV-A9W5	SKCM	TCGA	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.7982
p.H82R	DO228374	LICA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.8244
p.V85F	DO229029	LICA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.3056
p.L714I	DO229050	LICA	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation substituting flanking lysine	0.2222
p.G94C	DO25699	LUAD	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0556
p.G94V	DO232861	NACA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0556
p.R70H	DO232761	PBCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0833
p.W703C	DO38551	STAD	ICGC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.7
p.V87I	DO47819	STAD	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.25
p.A73D	DO229229	THCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.1667
p.R666C	DO41871	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	662:666	Mutation altering degron motif	0.8301
p.G73C	DO42472	UCEC	ICGC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.1667
p.R871H	SIDM00773	Non-Cancerous	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM01112	Osteosarcoma	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM00879	Breast Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM00032	Bladder Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM01503	Small Cell Lung Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.R871H	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.T891S	SIDM00761	Small Cell Lung Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6005
p.T891S	ACH-000752	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6005
p.T891S	NCI-H196	lung	COSMIC	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.6005
p.R716H	SIDM00203	Ewing's Sarcoma	GDSC	LKENG	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0556
p.V79A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6936
p.V79A	ACH-000918	Leukemia	CCLE	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6936
p.V79A	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation altering degron motif	0.6936
p.P94A	SIDM00302	Other Solid Cancers	GDSC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0556
p.P94A	ACH-002149	Ovarian Cancer	CCLE	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0556
p.P94A	KGN	ovary	COSMIC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0556
p.R70C	SIDM01664	Prostate Carcinoma	GDSC	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0833
p.R70C	ACH-000952	Prostate Cancer	CCLE	VPLHLD	LIG_APCC_ABBA_1	79:84	Mutation rewiring degron network	0.0833
p.S892N	ACH-000872	Lung Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.7069
p.Q895R	ACH-001063	Ovarian Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.25
p.T880K	ACH-001611	Brain Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LARP1B

UniProt ID: Q659C4

Entrez ID: 55132

Protein name: La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LARP1B in