DegronMD

Uniprot ID: Q659C4

Source protein: La-related protein 1B

Source gene: LARP1B

Class: LIG_APCC_ABBA_1

Location: 79:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 74.0833

COIL: 0.7427

CONS_SCORE: 0.4003

DSS_SCORE: 0.5721

HELIX: 0.1553

FCONS_SCORE: 1.2524

RIG_SCORE: 0.7736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A73S	TCGA-A5-A0G1	UCEC	TCGA	VPLHLD	LIG_APCC_ABBA_1	0.1667
p.H82Y	TCGA-GM-A2D9	BRCA	TCGA	VPLHLD	LIG_APCC_ABBA_1	0.6118
p.H82Y	DO4810	BRCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.6118
p.H82R	DO228374	LICA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.8244
p.V85F	DO229029	LICA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.3056
p.G94C	DO25699	LUAD	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.0556
p.G94V	DO232861	NACA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.0556
p.R70H	DO232761	PBCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.0833
p.V87I	DO47819	STAD	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.25
p.A73D	DO229229	THCA	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.1667
p.G73C	DO42472	UCEC	ICGC	VPLHLD	LIG_APCC_ABBA_1	0.1667
p.V79A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VPLHLD	LIG_APCC_ABBA_1	0.6936
p.V79A	ACH-000918	Leukemia	CCLE	VPLHLD	LIG_APCC_ABBA_1	0.6936
p.V79A	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VPLHLD	LIG_APCC_ABBA_1	0.6936
p.P94A	SIDM00302	Other Solid Cancers	GDSC	VPLHLD	LIG_APCC_ABBA_1	0.0556
p.P94A	ACH-002149	Ovarian Cancer	CCLE	VPLHLD	LIG_APCC_ABBA_1	0.0556
p.P94A	KGN	ovary	COSMIC	VPLHLD	LIG_APCC_ABBA_1	0.0556
p.R70C	SIDM01664	Prostate Carcinoma	GDSC	VPLHLD	LIG_APCC_ABBA_1	0.0833
p.R70C	ACH-000952	Prostate Cancer	CCLE	VPLHLD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q659C4	La-related protein 1B	LIG_APCC_ABBA_1	79:84	VPLHLD	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons