DegronMD

Uniprot ID: Q659C4

Source protein: La-related protein 1B

Source gene: LARP1B

Class: DEG_SPOP_SBC_1

Location: 876:880

E3 ligase: SPOP

DEGRON score: 0.9535

ASA_SCORE: 100.44

COIL: 0.9544

CONS_SCORE: 0.2784

DSS_SCORE: 0.8345

HELIX: 0.0332

FCONS_SCORE: 0.9789

RIG_SCORE: 0.4929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R871H	SIDM00773	Non-Cancerous	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM01112	Osteosarcoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM00879	Breast Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM00032	Bladder Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM01503	Small Cell Lung Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.R871H	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.T880K	ACH-001611	Brain Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons