DegronMD

Uniprot ID: Q05397

Source protein: Focal adhesion kinase 1

Source gene: PTK2

Class: DEG_SPOP_SBC_1

Location: 14:18

E3 ligase: SPOP

DEGRON score: 0.8344

ASA_SCORE: 72.02

COIL: 0.9116

CONS_SCORE: 0.267

DSS_SCORE: 0.6348

HELIX: 0.0564

FCONS_SCORE: 0.8727

RIG_SCORE: 0.6106

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L6V	TCGA-29-1698	OV	TCGA	PNSST	DEG_SPOP_SBC_1	0.5556
p.L6V	DO28531	OV	ICGC	PNSST	DEG_SPOP_SBC_1	0.5556
p.R28C	TCGA-A5-A0G2	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.0556
p.R28C	DO41235	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.0556
p.S16L	TCGA-AP-A1E0	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	TCGA-D1-A16X	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	TCGA-E6-A1LX	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	DO8730	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	DO41020	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	DO43154	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	DO41799	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	SIDM01043	Other Sarcomas	GDSC	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	ACH-000913	Endometrial/Uterine Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.8778
p.S16L	ESS-1	endometrium	COSMIC	PNSST	DEG_SPOP_SBC_1	0.8778
p.P14T	TCGA-IS-A3KA	SARC	TCGA	PNSST	DEG_SPOP_SBC_1	0.7031
p.P14T	DO220172	SARC	ICGC	PNSST	DEG_SPOP_SBC_1	0.7031
p.S15F	DO51925	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.7982
p.I14K	DO227987	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.7531
p.P25S	DO50357	ESAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.D7G	DO233089	GACA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.R28S	DO229041	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.0556
p.E9D	DO229044	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.6389
p.S15Y	DO46657	PAAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.712
p.S17Y	DO41133	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.712
p.P8S	SIDM01629	Melanoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.2778
p.P8S	ACH-000404	Skin Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.2778
p.N15S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PNSST	DEG_SPOP_SBC_1	0.5958

Drug responses associated with PTK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00210	UNCLASSIFIED\|ovary	p.S677G (No)	GDSC	PF-562271	3.2891
SIDM00087	MM\|myeloma	p.P731S (No)	GDSC	PF-562271	12.713
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.W613* (No)	GDSC	PF-562271	5.748
SIDM00381	CESC\|cervix	p.L1046P (No)	GDSC	PF-562271	11.5217
SIDM01090	COREAD\|large_intestine	p.P410H (No)	GDSC	PF-562271	2.6324
SIDM00995	UNCLASSIFIED\|skin_other	p.S745fs*36 (No)	GDSC	PF-562271	1.6673
SIDM00995	UNCLASSIFIED\|skin_other	p.M33fs*5 (No)	GDSC	PF-562271	1.6673
SIDM00516	SKCM\|melanoma	p.E809K (No)	GDSC	PF-562271	8.1771
SIDM01043	UNCLASSIFIED\|endometrium	p.S16L (Yes)	GDSC	PF-562271	4.0506
SIDM00518	MESO\|mesothelioma	p.A533S (No)	GDSC	PF-562271	5.77
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E544K (No)	GDSC	PF-562271	7.4519
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.S517C (No)	GDSC	PF-562271	43.9575
SIDM00889	CESC\|cervix	p.S307I (No)	GDSC	PF-562271	2.3525
SIDM00596	UCEC\|endometrium	p.S887N (No)	GDSC	PF-562271	7.126
SIDM00150	COREAD\|large_intestine	p.P116S (No)	GDSC	PF-562271	0.4899
SIDM00660	COREAD\|large_intestine	p.R811H (No)	GDSC	PF-562271	4.0457
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N46S (No)	GDSC	PF-562271	8.6162
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N15S (Yes)	GDSC	PF-562271	8.6162
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I21R (Yes)	GDSC	PF-562271	8.6162
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.I1038V (No)	GDSC	PF-562271	17.7554
SIDM00789	COREAD\|large_intestine	p.P2H (No)	GDSC	PF-562271	37.2504
SIDM00534	COREAD\|large_intestine	p.R597* (No)	GDSC	PF-562271	7.9391
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.C459G (No)	GDSC	PF-562271	5.5512
SIDM00414	BLCA\|bladder	p.C74W (No)	GDSC	PF-562271	3.2423
SIDM00480	OV\|ovary	p.R841Q (No)	GDSC	PF-562271	19.8104
SIDM00545	SKCM\|melanoma	p.P70S (No)	GDSC	PF-562271	60.8052
SIDM00448	DLBC\|B_cell_lymphoma	p.A551T (No)	GDSC	PF-562271	14.3947
SIDM00528	BRCA\|breast	p.F669L (No)	GDSC	PF-562271	10.9497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.P733T (No)	GDSC	PF-562271	3.2754
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.S522C (No)	GDSC	PF-562271	2.7144
SIDM01040	OV\|ovary	p.T979S (No)	GDSC	PF-562271	10.1862
SIDM00556	NB\|neuroblastoma	p.L1046P (No)	GDSC	PF-562271	20.8426
SIDM00118	COREAD\|large_intestine	p.Y548D (No)	GDSC	PF-562271	3.5879

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSST

Degron related mutations and impact score

Drug responses associated with PTK2 mutations

All proteins holding degron of PNSST