DegronMD - Q9UPQ9(TNRC6B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1727V	TCGA-60-2698	LUSC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1944
p.L1727V	DO26469	LUSC	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1944
p.A865V	TCGA-A5-A0G2	UCEC	TCGA	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation altering degron motif	0.5825
p.A865V	DO41235	UCEC	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation altering degron motif	0.5825
p.A1790T	TCGA-A5-A1OF	UCEC	TCGA	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation rewiring degron network	0.0833
p.A1790T	DO42568	UCEC	ICGC	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation rewiring degron network	0.0833
p.A1743V	TCGA-AJ-A23O	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1944
p.S1546R	TCGA-AN-A04D	BRCA	TCGA	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.0833
p.V1723A	TCGA-AP-A051	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.0833
p.V1723A	DO42673	UCEC	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.0833
p.R1620Q	TCGA-AP-A1DV	UCEC	TCGA	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.P1795S	TCGA-AX-A2HA	UCEC	TCGA	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation rewiring degron network	0.2222
p.P1795S	DO42504	UCEC	ICGC	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation rewiring degron network	0.2222
p.A1741V	TCGA-BR-4361	STAD	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.25
p.A1741V	DO38887	STAD	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.25
p.A1547S	TCGA-CC-A7IH	LIHC	TCGA	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.1111
p.A1547S	DO52181	LIHC	ICGC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.1111
p.Q246R	TCGA-CD-A4MG	STAD	TCGA	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.0556
p.Q246R	DO48009	STAD	ICGC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.0556
p.N540K	TCGA-D1-A103	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1944
p.N540K	DO42312	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1944
p.G861W	TCGA-D3-A2JL	SKCM	TCGA	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.G861W	TCGA-ER-A19F	SKCM	TCGA	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.G861W	TCGA-FE-A237	THCA	TCGA	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.G861W	DO37679	SKCM	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.G861W	DO47278	SKCM	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.G861W	DO40363	THCA	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.25
p.R1725G	TCGA-DA-A1I1	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1389
p.R1725G	DO37966	SKCM	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1389
p.P1735H	TCGA-EB-A24D	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation altering degron motif	0.7694
p.R1623S	TCGA-EE-A2ML	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1667
p.R1623S	DO37408	SKCM	ICGC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1667
p.F1562L	TCGA-EE-A3AH	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.25
p.F1562L	DO222635	MELA	ICGC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.25
p.F1562L	DO37443	SKCM	ICGC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.25
p.Q1729H	TCGA-EO-A3B0	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.25
p.P1603S	TCGA-ER-A42L	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.0556
p.P1603S	DO223910	SKCM	ICGC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.0556
p.P1739L	TCGA-FS-A1ZK	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.3056
p.P1739L	DO37474	SKCM	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.3056
p.Q541E	TCGA-HQ-A5NE	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.Q541E	DO51900	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.H544R	TCGA-QG-A5Z2	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.H544R	DO44096	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.P1610Q	TCGA-XK-AAIW	PRAD	TCGA	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.P1610Q	DO51407	PRAD	ICGC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.S1740G	TCGA-XP-A8T6	ESCA	TCGA	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.2778
p.Q530R	DO230309	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.3056
p.K542N	DO230326	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	531:535	Mutation substituting flanking lysine	0.25
p.A940V	DO222842	COCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.0833
p.M940L	DO229016	COCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.0833
p.T927I	DO50364	ESAD	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation altering degron motif	0.7078
p.Q915P	DO49663	LIAD	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.0556
p.S1791L	DO228650	LICA	ICGC	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation rewiring degron network	0.1111
p.N237Y	DO228946	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.3056
p.G857V	DO229027	LICA	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.1389
p.C245F	DO229034	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.0833
p.R1725L	DO228818	MALY	ICGC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1389
p.P862L	DO222402	MELA	ICGC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.2778
p.M940K	DO46376	OV	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.0833
p.R1623G	DO229459	SKCA	ICGC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1667
p.P929S	DO229462	SKCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation altering degron motif	0.6752
p.P931H	DO37440	SKCM	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation altering degron motif	0.7694
p.N924K	DO229221	THCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.3056
p.Q925H	DO219773	UCEC	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation altering degron motif	0.7582
p.A939V	DO43290	UCEC	ICGC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation substituting flanking lysine	0.2222
p.R1725H	SIDM00216	Colorectal Carcinoma	GDSC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1389
p.R1725H	SNU-175	large intestine	COSMIC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation rewiring degron network	0.1389
p.Y1565H	SIDM00321	Ovarian Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.1667
p.Y1565H	TYK-nu	ovary	COSMIC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.1667
p.T230S	SIDM00845	Burkitt's Lymphoma	GDSC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	SIDM00461	Acute Myeloid Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	SIDM01519	Head and Neck Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	ACH-000992	Head and Neck Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	S-117	soft tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.T230S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.2778
p.E870D	SIDM00845	Burkitt's Lymphoma	GDSC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation altering degron motif	0.6758
p.E870D	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation altering degron motif	0.6758
p.S1611A	SIDM00845	Burkitt's Lymphoma	GDSC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.2778
p.A1737V	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation altering degron motif	0.5825
p.A1737V	VAL	haematopoietic and lymphoid tissue	COSMIC	PPTPAAT	DEG_SCF_FBW7_1	1732:1738	Mutation altering degron motif	0.5825
p.S933L	SIDM01175	Other Sarcomas	GDSC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.S933L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.S933L	ACH-002309	Sarcoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.S933L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.S933L	SW684	soft tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.S1551C	SIDM01175	Other Sarcomas	GDSC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.2222
p.S1551C	SW684	soft tissue	COSMIC	VHSTS	DEG_SPOP_SBC_1	1555:1559	Mutation rewiring degron network	0.2222
p.T1807K	SIDM00924	Other Solid Cancers	GDSC	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation altering degron motif	0.7306
p.T1807K	ChaGo-K-1	lung	COSMIC	SSSLWGVPTV	DEG_COP1_1	1799:1808	Mutation altering degron motif	0.7306
p.P1610L	SIDM00006	Other Solid Cancers	GDSC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.P1610L	MCC26	skin	COSMIC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E870A	SIDM01140	Ovarian Carcinoma	GDSC	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation altering degron motif	0.7701
p.N1607S	SIDM01608	Endometrial Carcinoma	GDSC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1667
p.E922K	SIDM01619	Endometrial Carcinoma	GDSC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.25
p.E922K	ACH-000984	Endometrial/Uterine Cancer	CCLE	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.25
p.P862S	ACH-000928	Endometrial/Uterine Cancer	CCLE	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.2778
p.R921H	ACH-000989	Colon/Colorectal Cancer	CCLE	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2222
p.R921H	SNU-175	large intestine	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2222
p.A926P	ACH-001270	Sarcoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation altering degron motif	0.7503
p.M246T	ACH-001369	Ovarian Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	232:236	Mutation rewiring degron network	0.0556
p.T859A	ACH-001529	Endometrial/Uterine Cancer	CCLE	PATPKDE	DEG_SCF_FBW7_2	864:870	Mutation rewiring degron network	0.1944
p.A933V	ACH-001703	Lymphoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.A933V	VAL	haematopoietic and lymphoid tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	925:931	Mutation rewiring degron network	0.2778
p.P541L	ACH-002026	Endometrial/Uterine Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.A1627V	VAL	haematopoietic and lymphoid tissue	COSMIC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.0556
p.R1615H	SNU-175	large intestine	COSMIC	PWSST	DEG_SPOP_SBC_1	1613:1617	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNRC6B

UniProt ID: Q9UPQ9

Entrez ID: 23112

Protein name: Trinucleotide repeat-containing gene 6B protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNRC6B in