DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SPOP_SBC_1

Location: 1613:1617

E3 ligase: SPOP

DEGRON score: 0.9884

ASA_SCORE: 78.28

COIL: 0.9052

CONS_SCORE: 0.4665

DSS_SCORE: 0.6331

HELIX: 0.0626

FCONS_SCORE: 1.0069

RIG_SCORE: 0.6037

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1620Q	TCGA-AP-A1DV	UCEC	TCGA	PWSST	DEG_SPOP_SBC_1	0.25
p.R1623S	TCGA-EE-A2ML	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	0.1667
p.R1623S	DO37408	SKCM	ICGC	PWSST	DEG_SPOP_SBC_1	0.1667
p.P1603S	TCGA-ER-A42L	SKCM	TCGA	PWSST	DEG_SPOP_SBC_1	0.0556
p.P1603S	DO223910	SKCM	ICGC	PWSST	DEG_SPOP_SBC_1	0.0556
p.P1610Q	TCGA-XK-AAIW	PRAD	TCGA	PWSST	DEG_SPOP_SBC_1	0.25
p.P1610Q	DO51407	PRAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.25
p.R1623G	DO229459	SKCA	ICGC	PWSST	DEG_SPOP_SBC_1	0.1667
p.S1611A	SIDM00845	Burkitt's Lymphoma	GDSC	PWSST	DEG_SPOP_SBC_1	0.2778
p.P1610L	SIDM00006	Other Solid Cancers	GDSC	PWSST	DEG_SPOP_SBC_1	0.25
p.P1610L	MCC26	skin	COSMIC	PWSST	DEG_SPOP_SBC_1	0.25
p.N1607S	SIDM01608	Endometrial Carcinoma	GDSC	PWSST	DEG_SPOP_SBC_1	0.1667
p.A1627V	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	PWSST	DEG_SPOP_SBC_1	0.0556
p.R1615H	SNU-175	large_intestine	COSMIC	PWSST	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49335	POU domain, class 3, transcription factor 4	DEG_SPOP_SBC_1	66:70	PWSST	SPOP	0.5761	More...
Q13505	Metaxin-1	DEG_SPOP_SBC_1	19:23	PWSST	SPOP	0.8991	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1613:1617	PWSST	SPOP	0.9884	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	327:331	PWSST	SPOP	0.9984	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	359:363	PWSST	SPOP	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons