DegronMD - Q13505(MTX1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S22N	TCGA-EJ-5495	PRAD	TCGA	PWSST	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7069
p.S22N	DO36258	PRAD	ICGC	PWSST	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7069
p.G29R	DO23490	LINC	ICGC	PWSST	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.G13C	DO230525	LUSC	ICGC	PWSST	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.D22G	DO229257	THCA	ICGC	PWSST	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7198
p.P16S	DO41199	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.25
p.R11H	ACH-000980	Lung Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons