DegronMD

Uniprot ID: Q13505

Source protein: Metaxin-1

Source gene: MTX1

Class: DEG_SPOP_SBC_1

Location: 19:23

E3 ligase: SPOP

DEGRON score: 0.8991

ASA_SCORE: 68.58

COIL: 0.736

CONS_SCORE: 0.1253

DSS_SCORE: 0.7496

HELIX: 0.0804

FCONS_SCORE: 0.9436

RIG_SCORE: 0.5545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S22N	TCGA-EJ-5495	PRAD	TCGA	PWSST	DEG_SPOP_SBC_1	0.7069
p.S22N	DO36258	PRAD	ICGC	PWSST	DEG_SPOP_SBC_1	0.7069
p.G29R	DO23490	LINC	ICGC	PWSST	DEG_SPOP_SBC_1	0.1667
p.G13C	DO230525	LUSC	ICGC	PWSST	DEG_SPOP_SBC_1	0.1667
p.D22G	DO229257	THCA	ICGC	PWSST	DEG_SPOP_SBC_1	0.7198
p.P16S	DO41199	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	0.25
p.R11H	ACH-000980	Lung Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49335	POU domain, class 3, transcription factor 4	DEG_SPOP_SBC_1	66:70	PWSST	SPOP	0.5761	More...
Q13505	Metaxin-1	DEG_SPOP_SBC_1	19:23	PWSST	SPOP	0.8991	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	1613:1617	PWSST	SPOP	0.9884	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	327:331	PWSST	SPOP	0.9984	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	359:363	PWSST	SPOP	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons